Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky745
Abstract: Abstract Progress in oligonucleotide chemistry has produced a shift in the nature of siRNA used, from formulated, minimally modified siRNAs, to unformulated, heavily modified siRNA conjugates. The introduction of extensive chemical modifications is essential for… read more here.
Keywords: heavily modified; non modified; efficacy; cholesterol conjugated ... See more keywords
Cheminformatics Modeling of Gene Silencing for Both Natural and Chemically Modified siRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196412
Abstract: In designing effective siRNAs for a specific mRNA target, it is critically important to have predictive models for the potency of siRNAs. None of the published methods characterized the chemical structures of individual nucleotides constituting… read more here.
Keywords: cheminformatics modeling; chemically modified; gene silencing; natural chemically ... See more keywords