Modified U1 snRNA and antisense oligonucleotides rescue splice mutations in SLC26A4 that cause hereditary hearing loss
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DOI: 10.1002/humu.23774
Abstract: One of most important factors for messenger RNA (mRNA) transcription is the spliceosomal component U1 small nuclear RNA (snRNA), which recognizes 5′ splicing donor sites at specific regions in pre‐mRNA. Mutations in these sites disrupt… read more here.
Keywords: modified snrna; antisense oligonucleotides; hearing loss; snrna antisense ... See more keywords