Use of Gastrointestinal Simulator, Mass Transport Analysis, and Absorption Simulation to Investigate the Impact of pH Modifiers in Mitigating Weakly Basic Drugs' Performance Issues Related to Gastric pH: Palbociclib Case Study.
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DOI: 10.1021/acs.molpharmaceut.2c00545
Abstract: It is well known that reduced gastric acidity, for example with concomitant administration of acid reducing agents, can result in variable pharmacokinetics and decreased absorption of weakly basic drugs. It is important to identify the… read more here.
Keywords: dissolution; palbociclib; modifiers mitigating; absorption ... See more keywords