Modifying Antimicrobial Peptides with Albumin-Binding Molecules Enhances Membrane-Disrupting Efficacy by Modulating the Secondary Structure.
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DOI: 10.1021/acs.jmedchem.5c00407
Abstract: Antimicrobial peptides (AMPs) are powerful tools in combating drug-resistant bacteria. However, their clinical application is hindered by poor pharmacokinetics and suboptimal antimicrobial activity. This study proposes a strategy to enhance the antimicrobial activity and biosafety… read more here.
Keywords: binding molecules; modifying antimicrobial; efficacy; antimicrobial activity ... See more keywords