Histone Modifying Enzymes and Chromatin Modifiers in Glioma Pathobiology and Therapy Responses.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-30651-9_13
Abstract: Signal transduction pathways directly communicate and transform chromatin to change the epigenetic landscape and regulate gene expression. Chromatin acts as a dynamic platform of signal integration and storage. Histone modifications and alteration of chromatin structure… read more here.
Keywords: enzymes chromatin; histone modifying; chromatin modifiers; modifying enzymes ... See more keywords
Association of blaNDM-1 with blaKPC-2 and aminoglycoside-modifying enzymes genes among Klebsiella pneumoniae, Proteus mirabilis and Serratia marcescens clinical isolates in Brazil.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2019.08.026
Abstract: OBJECTIVE Carbapenemase producingEnterobacterales are often involved in healthcare-associated infections worldwide. Therefore, the objective of this study was to investigate the frequency of the main genes for carbapenemases, methylases, aminoglycoside-modifying enzymes (AMEs), and mcr gene, as… read more here.
Keywords: blandm blakpc; modifying enzymes; aminoglycoside modifying; mirabilis ... See more keywords
Metabolic intermediates – Cellular messengers talking to chromatin modifiers
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2018.01.007
Abstract: Background To maintain homeostasis, cells need to coordinate the expression of their genes. Epigenetic mechanisms controlling transcription activation and repression include DNA methylation and post-translational modifications of histones, which can affect the architecture of chromatin… read more here.
Keywords: intermediates cellular; chromatin; metabolic intermediates; modifying enzymes ... See more keywords
Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.01.07.475340
Abstract: Antibiotics consumption and its abuses have been historically and repeatedly pointed out as the major driver of antibiotic resistance emergence and propagation. However, several examples show that resistance may persist despite substantial reductions in antibiotic… read more here.
Keywords: antibiotics consumption; ecology; consumption; modifying enzymes ... See more keywords
Rapid characterization of the activities of lignin-modifying enzymes based on nanostructure-initiator mass spectrometry (NIMS)
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology for Biofuels"
DOI: 10.1186/s13068-018-1261-2
Abstract: BackgroundProducing valuable fuels and chemicals from lignin is a key factor for making lignocellulosic biomass economically feasible; however, significant roadblocks exist due to our lack of detailed understanding of how lignin is enzymatically depolymerized and… read more here.
Keywords: carbon; modifying enzymes; lignin modifying; reaction ... See more keywords
Role of aminoglycoside-modifying enzymes and 16S rRNA methylase (ArmA) in resistance of Acinetobacter baumannii clinical isolates against aminoglycosides
Sign Up to like & getrecommendations! Published in 2021 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0599-2020
Abstract: Abstract INTRODUCTION: This study aimed to determine the role of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S rRNA methylase (ArmA) in Acinetobacter baumannii clinical isolates. METHODS: We collected 100 clinical isolates of A. baumannii and… read more here.
Keywords: modifying enzymes; arma; 16s rrna; aminoglycoside modifying ... See more keywords
Prevalence of Aminoglycoside Resistance and Aminoglycoside Modifying Enzymes in Acinetobacter baumannii Among Intensive Care Unit Patients, Ismailia, Egypt
Sign Up to like & getrecommendations! Published in 2021 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s290584
Abstract: Background Acinetobacter baumannii is an opportunistic pathogen that rapidly develops antibiotic resistance against commonly prescribed antimicrobial agents in hospitalized patients worldwide. Aminoglycosides are commonly used in the treatment of A. baumannii health care-associated infections (HAIs).… read more here.
Keywords: care; baumannii; modifying enzymes; resistance ... See more keywords
Ubiquitin-modifying enzymes in Huntington’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1107323
Abstract: Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the N-terminus of the HTT gene. The CAG repeat expansion translates into a polyglutamine expansion in the mutant HTT (mHTT) protein,… read more here.
Keywords: huntington disease; ubiquitin modifying; modifying enzymes; expansion ... See more keywords
Aminoglycoside-Modifying Enzymes Are Sufficient to Make Pseudomonas aeruginosa Clinically Resistant to Key Antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11070884
Abstract: Aminoglycosides are widely used to treat infections of Pseudomonas aeruginosa. Genes encoding aminoglycoside-modifying enzymes (AMEs), acquired by horizontal gene transfer, are commonly associated with aminoglycoside resistance, but their effects have not been quantified. The aim… read more here.
Keywords: pseudomonas aeruginosa; aminoglycoside modifying; resistance; modifying enzymes ... See more keywords
The Role of DNA/Histone Modifying Enzymes and Chromatin Remodeling Complexes in Testicular Germ Cell Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Cancers"
DOI: 10.3390/cancers11010006
Abstract: It is well established that cancer cells exhibit alterations in chromatin structure and accessibility. Indeed, the dysregulation of many protein-coding players with enzymatic activity (DNA and histone-modifying enzymes) and chromatin remodelers have been depicted in… read more here.
Keywords: enzymes chromatin; dna; histone modifying; modifying enzymes ... See more keywords
The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers14010006
Abstract: Simple Summary Microtubules are tubulin polymers that constitute the structure of eukaryotic cells. They control different cell functions that are often deregulated in cancer, such as cell shape, cell motility and the intracellular movement of… read more here.
Keywords: cancer; tubulin; tubulin code; cell ... See more keywords