Modular DNA Circuits for Point-of-Care Colorimetric Assay of Infectious Pathogens.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c02597
Abstract: Accurate, specific, and inexpensive detection of multiple infectious pathogens simultaneously is a significant goal for human health and safety. Herein we present a rationally designed modular DNA circuit for point-of-care (POC) detection of a variety… read more here.
Keywords: point care; modular dna; infectious pathogens; detection ... See more keywords
FRAGLER: A Fragment Recycler Application Enabling Rapid and Scalable Modular DNA Assembly.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00106
Abstract: Rapid and flexible plasmid construct generation at scale is one of the most limiting first steps in drug discovery projects. These hurdles can partly be overcome by adopting modular DNA design principles, automated sequence fragmentation,… read more here.
Keywords: generation; fragler fragment; modular dna; fragment recycler ... See more keywords
Modular DNA-Origami-Based Nanoarrays Enhance Cell Binding Affinity through the "Lock-and-Key" Interaction.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13825
Abstract: Surface proteins of cells are generally recognized through receptor-ligand interactions (RLIs) in disease diagnosis, but their nonuniform spatial distribution and higher-order structure lead to low binding affinity. Constructing nanotopologies that match the spatial distribution of… read more here.
Keywords: origami based; binding affinity; affinity; modular dna ... See more keywords
Three-dimensional DNA tweezers serve as modular DNA intelligent machines for detection and regulation of intracellular microRNA.
Sign Up to like & getrecommendations! Published in 2020 at "Science advances"
DOI: 10.1126/sciadv.abb0695
Abstract: MicroRNAs (miRNAs) as novel biological targets are hardly applied in diagnostic and treatment of diseases, as they are difficult to be accurately detected and regulated. Here, we demonstrated a modular DNA intelligent machine named three-dimensional… read more here.
Keywords: three dimensional; dna; detection regulation; dna intelligent ... See more keywords