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   Articles with "modular polyketide" as a keyword



Protein‐Protein Recognition Involved in the Intermodular Transacylation Reaction in Modular Polyketide Synthase in the Biosynthesis of Vicenistatin

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recommendations! Published in 2022 at "Chembiochem"

DOI: 10.1002/cbic.202200200

Abstract: The ketosynthase (KS) domain is a core domain found in modular polyketide synthases (PKSs). To maintain the polyketide biosynthetic fidelity, the KS domain must only accept an acyl group from the acyl carrier protein (ACP)… read more here.

Keywords: protein protein; domain; transacylation; transacylation reaction ... See more keywords
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Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.

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recommendations! Published in 2018 at "Journal of structural biology"

DOI: 10.1016/j.jsb.2018.04.001

Abstract: Ketoreductase (KR) domains of modular polyketide synthases (PKSs) control the stereochemistry of C2 methyl and C3 hydroxyl substituents of polyketide intermediates. To understand the molecular basis of stereocontrol exerted by KRs, the crystal structure of… read more here.

Keywords: polyketide; structures ketoreductase; bound structures; substrate bound ... See more keywords
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Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases

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recommendations! Published in 2020 at "Synthetic and Systems Biotechnology"

DOI: 10.1016/j.synbio.2020.04.001

Abstract: Modular polyketide synthases (PKSs) are a multidomain megasynthase class of biosynthetic enzymes that have great promise for the development of new compounds, from new pharmaceuticals to high value commodity and specialty chemicals. Their colinear biosynthetic… read more here.

Keywords: protein; synthetic biology; modular polyketide; biology ... See more keywords

Structural Basis of Transient Interactions of Acyltransferase VinK with the Loading Acyl Carrier Protein of the Vicenistatin Modular Polyketide Synthase.

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recommendations! Published in 2022 at "Biochemistry"

DOI: 10.1021/acs.biochem.2c00645

Abstract: Acyltransferase (AT) recognizes its cognate acyl carrier protein (ACP) for functional transfer of an acyl unit in polyketide biosynthesis. However, structural characterization of AT-ACP complexes is limited because of the weak and transient interactions between… read more here.

Keywords: vink; vink vinp1acpl; transient interactions; acp ... See more keywords

Directed Evolution of a Modular Polyketide Synthase Thioesterase for Generation of a Hybrid Macrocyclic Ring System.

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recommendations! Published in 2025 at "ACS catalysis"

DOI: 10.1021/acscatal.4c07922

Abstract: Modular type I polyketide synthases (PKSs) comprise a family of enzymes that synthesize a diverse class of natural products with medicinal applications. The biochemical features of these systems include the extension and processing of polyketide… read more here.

Keywords: evolution; modular polyketide; evolution modular; polyketide ... See more keywords