Modular Synthesis of [6,6]‐Oxaspirolactones Enabled by Palladium‐Catalyzed Carbonylative Spirolactonization
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DOI: 10.1002/cctc.202400627
Abstract: An expedient and efficient carbonylative protocol proceeded via palladium‐catalyzed tandem cyclic ketonization and carbonylative spirolactonization has been developed. This carbonylation reaction is compatible with a wide range of hydroxyalkyl ketone tethered benzyl chlorides bearing different… read more here.
Keywords: modular synthesis; synthesis oxaspirolactones; palladium catalyzed; carbonylative spirolactonization ... See more keywords
Modular Synthesis of Tetracyclic Heteroarenes via Platinum‐Catalyzed Cyclization of Ethynylbiaryl Precursors
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202401114
Abstract: Polycyclic heteroarenes that contain internal thiophene, furan and pyrrole rings are well‐documented materials due to their presence in fossil fuels and their importance in organic optoelectronic applications. Accordingly, a variety of methods are available for… read more here.
Keywords: tetracyclic heteroarenes; cyclization; synthesis; side product ... See more keywords
Modular Synthesis of Least Restrictive Controllable and Nonblocking Supervisors with Distinguishers
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DOI: 10.1016/j.ifacol.2021.04.020
Abstract: Abstract This paper proposes algorithms for supervisor synthesis in discrete event system models with distinguishers. Distinguishers are special components responsible to select an enabled event from a group of related refined events. They are a… read more here.
Keywords: nonblocking supervisors; restrictive controllable; synthesis; least restrictive ... See more keywords
Metastable Inventions: Simondonian concretisation and technical invention in modular synthesis practice
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DOI: 10.1017/s1355771824000128
Abstract: This article analyses the author’s modular synthesis practice through the lens of Simondonian philosophy, arguing that modular synthesis represents a dynamic example of technical ontogenesis in artistic practice. With its emphasis on technical becoming, Gilbert… read more here.
Keywords: technical invention; synthesis; philosophy; modular synthesis ... See more keywords
Modular Synthesis of Bioactive Selenoheterocycles for Efficient Cancer Therapy via Electrochemical Selenylation/Cyclization.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02724
Abstract: A green, efficient, and environmentally friendly electrochemical strategy was developed for synthesizing a series of selenoheterocyclic compounds. The antitumor activities of these compounds were evaluated, revealing that compounds 4o, 5n, and 5o demonstrated remarkable antitumor… read more here.
Keywords: cancer; bioactive selenoheterocycles; synthesis bioactive; efficient cancer ... See more keywords
Short and Modular Synthesis of Substituted 2-Aminopyrroles
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DOI: 10.1021/acs.orglett.1c01345
Abstract: We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach,… read more here.
Keywords: methodology; modular synthesis; synthesis substituted; short modular ... See more keywords
A Modular Synthesis of the Rhazinilam Family of Alkaloids and Analogs Thereof.
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DOI: 10.1021/acs.orglett.2c02446
Abstract: A short, modular strategy for synthesizing three representative alkaloids of the (±)-rhazinilam family and 10 non-natural analogs is described. The protocol involves a radical addition/cyclization cascade reaction that assembles the tetrahydroindolizine system decorated with appropriate… read more here.
Keywords: family; alkaloids analogs; rhazinilam family; family alkaloids ... See more keywords
Modular Synthesis of Polar Spirocyclic Scaffolds Enabled by Radical Chemistry.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00869
Abstract: Herein, we report a highly modular strategy to access spirocyclic scaffolds from abundant starting materials, i.e., cyclic ketones and α-amino or oxamic acids. The sequence proceeds through a straightforward Knoevenagel condensation, followed by a domino… read more here.
Keywords: spirocyclic scaffolds; chemistry; polar spirocyclic; scaffolds enabled ... See more keywords
Modular Synthesis and Antimicrobial Investigation of Mycoleptodiscin A and Simplified Indolosesquiterpenoids.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c01932
Abstract: The structure-activity relationship of the unusual indolosesquiterpenoid mycoleptodiscin A is unknown due to natural scarcity and inefficient synthesis. A modular approach leveraging Larock indole synthesis has been established to access mycoleptodiscin A and a divergent… read more here.
Keywords: antimicrobial investigation; mycoleptodiscin; synthesis; synthesis antimicrobial ... See more keywords
Modular Synthesis of Polysubstituted α-Phosphorylated Arenes via the Catellani Strategy.
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DOI: 10.1021/acs.orglett.4c01944
Abstract: In this paper, we described a palladium/norbornene-catalyzed ortho-C-H phosphormethylation of aryl iodides using XCH2P(O)RR', offering a reliable method for the modular synthesis of polysubstituted α-phosphorylated arenes. Alkenylation, hydrogenation, cyanation, methylation, and arylation were all viable… read more here.
Keywords: arenes via; synthesis polysubstituted; polysubstituted phosphorylated; modular synthesis ... See more keywords
A Modular Synthesis of Planar, Redox-Stable Hückel Anti-Aromatic [36]Nonaphyrin (1.0.0.1.0.0.1.0.0) with Only Three meso-Bridges.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c00170
Abstract: A rigid dithienopyrrole (DTP) subunit was functionalized by taking advantage of the fused core, which upon Lewis acid-catalyzed self-condensation afforded two structurally distinct expanded porphyrinoids, namely [36]nonaphyrin (S6N3) and [48]dodecaphyrin (S8N4). The single crystal X-ray… read more here.
Keywords: anti aromatic; planar redox; synthesis planar; redox stable ... See more keywords