Modular Synthesis of Least Restrictive Controllable and Nonblocking Supervisors with Distinguishers
Sign Up to like & getrecommendations! Published in 2020 at "IFAC-PapersOnLine"
DOI: 10.1016/j.ifacol.2021.04.020
Abstract: Abstract This paper proposes algorithms for supervisor synthesis in discrete event system models with distinguishers. Distinguishers are special components responsible to select an enabled event from a group of related refined events. They are a… read more here.
Keywords: nonblocking supervisors; restrictive controllable; synthesis; least restrictive ... See more keywords
Short and Modular Synthesis of Substituted 2-Aminopyrroles
Sign Up to like & getrecommendations! Published in 2021 at "Organic Letters"
DOI: 10.1021/acs.orglett.1c01345
Abstract: We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach,… read more here.
Keywords: methodology; modular synthesis; synthesis substituted; short modular ... See more keywords
A Modular Synthesis of the Rhazinilam Family of Alkaloids and Analogs Thereof.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02446
Abstract: A short, modular strategy for synthesizing three representative alkaloids of the (±)-rhazinilam family and 10 non-natural analogs is described. The protocol involves a radical addition/cyclization cascade reaction that assembles the tetrahydroindolizine system decorated with appropriate… read more here.
Keywords: family; alkaloids analogs; rhazinilam family; family alkaloids ... See more keywords
Modular Synthesis of Polar Spirocyclic Scaffolds Enabled by Radical Chemistry.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00869
Abstract: Herein, we report a highly modular strategy to access spirocyclic scaffolds from abundant starting materials, i.e., cyclic ketones and α-amino or oxamic acids. The sequence proceeds through a straightforward Knoevenagel condensation, followed by a domino… read more here.
Keywords: spirocyclic scaffolds; chemistry; polar spirocyclic; scaffolds enabled ... See more keywords
Highly Modular Synthesis of 1,2-Diketones via Multicomponent Coupling Reactions of Isocyanides as CO Equivalents
Sign Up to like & getrecommendations! Published in 2019 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b00581
Abstract: A one-pot, four-component Pd-catalyzed coupling has been developed for the synthesis of unsymmetrical 1,2-diketones from aryl halides and alkyl zincs employing tert-butyl isocyanide as a CO source. The intermediate 1,2-diketones have been elaborated to quinoxalines.… read more here.
Keywords: synthesis; synthesis diketones; diketones via; via multicomponent ... See more keywords
Modular Synthesis of 2,8-Dioxabicyclo[3.2.1]octanes by Sequential Catalysis
Sign Up to like & getrecommendations! Published in 2019 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b04183
Abstract: A modular synthesis of 2,8-dioxabicyclo[3.2.1]octane (2,8-DOBCO) ketals is realized by sequential catalysis. The key intermediates, e-hydroxyl-β,γ-unsaturated ketones, are readily available by Ni-catalyzed three-component coupling of 1,3-dienes, aldehydes, and acylzirconocene reagents. These polyfunctionalized ketones can undergo… read more here.
Keywords: sequential catalysis; modular synthesis; synthesis dioxabicyclo; catalysis ... See more keywords
Modular Synthesis of Benzocyclobutenes via Pd(II)-Catalyzed Oxidative [2+2] Annulation of Arylboronic Acids with Alkenes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03565
Abstract: Benzocyclobutenes (BCBs) are highly valuable compounds in organic synthesis, medicinal chemistry, and materials science. However, catalytic modular synthesis of functionalized BCBs from easily accessible starting materials remains limited. We report herein an efficient synthesis of… read more here.
Keywords: synthesis; acids alkenes; arylboronic acids; annulation arylboronic ... See more keywords
Modular Synthesis of Unnatural Peptides via Rh(III)-Catalyzed Diastereoselective Three-Component Carboamidation Reaction.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10793
Abstract: Herein we report a modular peptide ligation methodology that couples dioxazolones, arylboronic acids, and acrylamides to construct amide bonds in a diastereoselective manner under mild conditions, facilitated by Rh(III) catalysis. By converting the C-terminus of… read more here.
Keywords: synthesis unnatural; unnatural peptides; methodology; peptides via ... See more keywords
s-Indacene Revisited: Modular Synthesis and Modulation of Structures and Molecular Orbitals of Hexaaryl Derivatives.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13159
Abstract: Though s-indacene is an intriguing antiaromatic hydrocarbon of 12 π-electrons, it has been underrepresented due to the lack of efficient and versatile methods to prepare stable derivatives. Herein we report a concise and modular synthetic… read more here.
Keywords: modulation; homo; indacene revisited; indacene derivatives ... See more keywords
Synthetic and Spectroscopic Investigations Enabled by Modular Synthesis of Molecular Phosphaalkyne Precursors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b09845
Abstract: A series of dibenzo-7-phosphanorbornadiene compounds, Ph3PC(R)PA (1-R; A = C14H10, anthracene; R = Me, Et, iPr, sBu), are reported to be capable of thermal fragmentation to generate alkyl-substituted phosphaalkynes (RC≡P) concomitant with triphenylphosphine and anthracene.… read more here.
Keywords: investigations enabled; modular synthesis; synthetic spectroscopic; spectroscopic investigations ... See more keywords
A modular synthesis of tetracyclic meroterpenoid antibiotics
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02061-7
Abstract: Stachyflin, aureol, smenoqualone, strongylin A, and cyclosmenospongine belong to a family of tetracyclic meroterpenoids, which, by nature of their unique molecular structures and various biological properties, have attracted synthetic and medicinal chemists alike. Despite their… read more here.
Keywords: modular synthesis; meroterpenoid antibiotics; synthesis tetracyclic; synthesis ... See more keywords