PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages
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DOI: 10.3389/fimmu.2021.649572
Abstract: NLRP3 inflammasomes play crucial roles in the initiation of host defense by converting pro-Caspase-1 to mature Caspase-1, which in turn processes immature IL-1β and IL-18 into their biologically active forms. Although NLRP3 expression is restricted… read more here.
Keywords: irf8 modulate; expression nlrp3; modulate activation; expression ... See more keywords