Cross-Reactivity of Alpha-Synuclein with Other Cellular Components Can Dramatically Modulate Amyloid Formation
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1980
Abstract: The aggregation process, going from monomers to amyloid fibers, of the protein α-synuclein (αS) somehow causes degeneration of dopaminergic neurons in Parkinson's disease patients. The exact activities of αS are not yet identified, but synapse… read more here.
Keywords: cross reactivity; modulate amyloid; formation; parkinson disease ... See more keywords
(Bio)Chemical strategies to modulate amyloid-β self-assembly.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00239
Abstract: Amyloid plaques are one of the two hallmarks of Alzheimer's disease (AD). They consist mainly of fibrils made of self-assembled amyloid-β (Aβ) peptides. Aβ is produced in healthy brains from proteolytic cleavage of the amyloid… read more here.
Keywords: modulate amyloid; self assembly; chemical strategies; self ... See more keywords