Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2019.12.004
Abstract: Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). GBA1 encodes the lysosomal lipid hydrolase glucocerebrosidase (GCase), and its activity has been… read more here.
Keywords: synuclein; activity modulates; activity; neuronal susceptibility ... See more keywords
The insecticide esfenvalerate modulates neuronal excitability in mammalian central nervous system in vitro.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2016.12.012
Abstract: Pyrethroids are neurotoxic insecticides showing significant selective toxicity on insects over mammals, but effects on mammalian nervous system are not negligible. These substances act on the voltage-gated sodium channel, prolonging the duration of the open… read more here.
Keywords: insecticide esfenvalerate; nervous system; esfenvalerate modulates; excitability ... See more keywords
PRMT7 modulates neuronal excitability by interacting with NaV1.9.
Sign Up to like & getrecommendations! Published in 2021 at "Pain"
DOI: 10.1097/j.pain.0000000000002421
Abstract: ABSTRACT Human NaV1.9 (hNaV1.9), encoded by SCN11A, is preferentially expressed in nociceptors, and its mutations have been linked to pain disorders. NaV1.9 could be a promising drug target for pain relief. However, the modulation of… read more here.
Keywords: neuronal excitability; scn11a mice; prmt7 modulates; prmt7 ... See more keywords
Zingerone Modulates Neuronal Voltage-Gated Na+ and L-Type Ca2+ Currents
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DOI: 10.3390/ijms23063123
Abstract: Zingerone (ZO), a nontoxic methoxyphenol, has been demonstrated to exert various important biological effects. However, its action on varying types of ionic currents and how they concert in neuronal cells remain incompletely understood. With the… read more here.
Keywords: modulates neuronal; hysteresis; ionic currents; voltage gated ... See more keywords
Spatial Attention Modulates Neuronal Interactions between Simple and Complex Cells in V1
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098229
Abstract: Visual perception is profoundly modulated by spatial attention, which can selectively prioritize goal-related information. Previous studies found spatial attention facilitated the efficacy of neuronal communication between visual cortices with hierarchical organizations. In the primary visual… read more here.
Keywords: simple complex; spatial attention; attention modulates; complex cells ... See more keywords