The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia
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DOI: 10.1182/bloodadvances.2023011540
Abstract: Key Points • In murine AML models, Herc1 modulates nucleoside analog resistance and levels of deoxycitidine kinase, their rate-limiting metabolic enzyme.• HERC1 is highly expressed in human AML and its elevated expression is associated with… read more here.
Keywords: herc1; response nucleoside; modulates response; herc1 modulates ... See more keywords
Vitamin D Modulates the Response of Patient-Derived Metastatic Melanoma Cells to Anticancer Drugs
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DOI: 10.3390/ijms24098037
Abstract: Melanoma is considered a lethal and treatment-resistant skin cancer with a high risk of recurrence, making it a major clinical challenge. Our earlier studies documented that 1,25(OH)2D3 and its low-calcaemic analogues potentiate the effectiveness of… read more here.
Keywords: melanoma; vitamin modulates; response patient; patient derived ... See more keywords