Stereochemical Control of Splice Modulation in FD-895 Analogues.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01893
Abstract: Highly functionalized skeletons of macrolide natural products gain access to rare spatial arrangements of atoms, where changes in stereochemistry can have a profound impact on the structure and function. Spliceosome modulators present a unique consensus… read more here.
Keywords: 895 analogues; control splice; modulation 895; chemistry ... See more keywords