Hormonal Modulation of ESR1 Mutant Metastasis
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DOI: 10.1038/s41388-020-01563-x
Abstract: Estrogen receptor alpha gene (ESR1) mutations occur frequently in ER-positive metastatic breast cancer, and confer clinical resistance to aromatase inhibitors. Expression of the ESR1 Y537S mutation induced an epithelial–mesenchymal transition (EMT) with cells exhibiting enhanced… read more here.
Keywords: modulation esr1; breast cancer; metastasis; esr1 mutant ... See more keywords