Probing the Allosteric Modulation of P-Glycoprotein: A Medicinal Chemistry Approach Toward the Identification of Noncompetitive P-Gp Inhibitors
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DOI: 10.1021/acsomega.2c08273
Abstract: A medicinal chemistry approach combining in silico and in vitro methodologies was performed aiming at identifying and characterizing putative allosteric drug-binding sites (aDBSs) at the interface of the transmembrane- and nucleotide-binding domains (TMD-NBD) of P-glycoprotein.… read more here.
Keywords: modulation glycoprotein; chemistry; medicinal chemistry; chemistry approach ... See more keywords