Positive Modulation of Human Nav Channels by Pyrethroids
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1315
Abstract: Voltage-gated sodium channels (Nav) are crucial to the initiation and propagation of action potentials in electrically excitable cells. Inhibitors of such ion channels have been developed and approved as drugs to treat a variety of… read more here.
Keywords: modulation human; positive modulation; human nav; sodium channel ... See more keywords
Modulation of human macrophage activity by Ascaris antigens is dependent on macrophage polarization state.
Sign Up to like & getrecommendations! Published in 2018 at "Immunobiology"
DOI: 10.1016/j.imbio.2017.11.003
Abstract: Parasitic worms (helminths) are known to actively modulate host immune responses and inflammation. The aim of this study was to investigate if adult body fluid (ABF) from the helminth Ascaris suum has immunomodulatory effects on… read more here.
Keywords: polarization; modulation human; macrophage; macrophage activity ... See more keywords
Chemical Modulation of the Human Oligopeptide Transporter 1, hPepT1.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00775
Abstract: In humans, peptides derived from dietary proteins and peptide-like drugs are transported via the proton-dependent oligopeptide transporter hPepT1 (SLC15A1). hPepT1 is located across the apical membranes of the small intestine and kidney, where it serves… read more here.
Keywords: oligopeptide transporter; hpept1; transporter hpept1; modulation human ... See more keywords
Chemical Modulation of the Human Mitochondrial ClpP: Potential Application in Cancer Therapeutics.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00347
Abstract: The human ClpP proteolytic complex (HsClpP) is a serine protease located in the mitochondrial matrix and participates in the maintenance of the mitochondrial proteome among other cellular functions. HsClpP typically forms a multimeric complex with… read more here.
Keywords: hsclpp; modulation human; clpp; chemical modulation ... See more keywords
Endogenous modulation of human visual cortex activity improves perception at twilight
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03660-8
Abstract: Perception, particularly in the visual domain, is drastically influenced by rhythmic changes in ambient lighting conditions. Anticipation of daylight changes by the circadian system is critical for survival. However, the neural bases of time-of-day-dependent modulation… read more here.
Keywords: perception; modulation human; dawn dusk; activity ... See more keywords
Differential Modulation of Human M1 and M2 Macrophage Activity by ICOS-Mediated ICOSL Triggering
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032953
Abstract: Activated T cells express the inducible T-cell co-stimulator (ICOS) that, upon binding to its ubiquitously expressed ligand (ICOSL), regulates the immune response and tissue repair. We sought to determine the effect of ICOS:ICOSL interaction on… read more here.
Keywords: icos; icos ch3; activity; modulation human ... See more keywords