Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model.
Sign Up to like & getrecommendations! Published in 2021 at "Neuropathology and applied neurobiology"
DOI: 10.1111/nan.12747
Abstract: AIMS Mitochondrial dysfunction and inflammation are at the core of axonal degeneration in several multifactorial neurodegenerative diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease. The transcriptional coregulator RIP140/NRIP1 (receptor-interacting protein 140) modulates these functions in… read more here.
Keywords: modulation mitochondrial; adrenoleukodystrophy; model; rip140 ... See more keywords
Modulation of Mitochondrial Membrane Potential and ROS Generation by Nicotinamide in a Manner Independent of SIRT1 and Mitophagy
Sign Up to like & getrecommendations! Published in 2017 at "Molecules and Cells"
DOI: 10.14348/molcells.2017.0081
Abstract: Nicotinamide (NAM) plays essential roles in physiology through facilitating NAD+ redox homeostasis. Importantly, at high doses, it protects cells under oxidative stresses, and has shown therapeutic effectiveness in a variety of disease conditions. In our… read more here.
Keywords: modulation mitochondrial; generation; physiology; activation ... See more keywords
Modulation of mitochondrial bioenergetics as a therapeutic strategy in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.224362
Abstract: Alzheimer's disease (AD) is an increasingly pressing worldwide public-health, social, political and economic concern. Despite significant investment in multiple traditional therapeutic strategies that have achieved success in preclinical models addressing the pathological hallmarks of the… read more here.
Keywords: modulation mitochondrial; mitochondrial bioenergetics; alzheimer disease; disease ... See more keywords