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   Articles with "modulation nrf2" as a keyword



Controversy about pharmacological modulation of Nrf2 for cancer therapy

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recommendations! Published in 2017 at "Redox Biology"

DOI: 10.1016/j.redox.2017.04.013

Abstract: Conventional anticancer therapies such as radiotherapy and chemotherapies are associated with oxidative stress generating reactive oxygen species (ROS) and reactive aldehydes like 4-hydroxynonenal in cancer cells that govern them to die. The main mechanism activated… read more here.

Keywords: therapy; nrf2 cancer; controversy pharmacological; modulation nrf2 ... See more keywords

Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2

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recommendations! Published in 2020 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s230358

Abstract: Background Oxidative stress is a major contributor to the onset and development of myocardial ischemia reperfusion injury (MIRI). Sappanone A (SA), a homoisoflavanone extracted from the heartwood of Caesalpinia sappan L., has been demonstrated to… read more here.

Keywords: ischemia; myocardial ischemia; reperfusion injury; ischemia reperfusion ... See more keywords

Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer

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recommendations! Published in 2023 at "Antioxidants"

DOI: 10.3390/antiox12030735

Abstract: Oxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways to moderate the defects of these stresses during their evolution.… read more here.

Keywords: lung cancer; natural compounds; nrf2 natural; modulation nrf2 ... See more keywords

Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis

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recommendations! Published in 2024 at "Antioxidants"

DOI: 10.3390/antiox13101270

Abstract: Periodontitis affects up to 40% of adults over 60 years old and is a consequence of gingivitis. Periodontitis is characterized by a chronic inflammation, periodontal damage, and alveolar bone resorption. The nuclear factor erythroid 2-related… read more here.

Keywords: modulation nrf2; keap1 signaling; periodontitis; signaling phytotherapeutics ... See more keywords

Quercetin Is An Active Agent in Berries against Neurodegenerative Diseases Progression through Modulation of Nrf2/HO1

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recommendations! Published in 2022 at "Nutrients"

DOI: 10.3390/nu14235132

Abstract: Berries are well-known fruits for their antioxidant effects due to their high content of flavonoids, and quercetin is one of the potent bioactive flavonoids. Although oxidative stress is an inevitable outcome in cells due to… read more here.

Keywords: stress; progression; oxidative stress; nrf2 ho1 ... See more keywords