Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease
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DOI: 10.1111/jcmm.13209
Abstract: Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which impairs cytosolic sequestration of the repressor element‐1 silencing transcription factor (REST), resulting in excessive nuclear REST and subsequent… read more here.
Keywords: modulation nuclear; nuclear rest; huntington disease; rest ... See more keywords
Drug modulation by nuclear condensates
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abc5318
Abstract: Concentration of antineoplastic agents into spatial compartments influences activity Many mysteries remain about the eukaryotic nucleus. In the past decade, much has been discovered anew about the three-dimensional (3D) organization of the nucleus and the… read more here.
Keywords: drug; drug modulation; modulation nuclear; nuclear condensates ... See more keywords