Splicing Modulation Results in Aberrant Isoforms and Protein Products of p53 Pathway Genes and the Sensitization of B Cells to Non-Genotoxic MDM2 Inhibition
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DOI: 10.3390/ijms24032410
Abstract: Several molecular subtypes of cancer are highly dependent on splicing for cell survival. There is a general interest in the therapeutic targeting of splicing by small molecules. E7107, a first-in-class spliceosome inhibitor, showed strong growth… read more here.
Keywords: mdm2 inhibition; splicing modulation; mdm2; modulation results ... See more keywords