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   Articles with "modulation synuclein" as a keyword



Modulation of α-Synuclein Fibrillation by Ultrasmall and Biocompatible Gold Nanoclusters.

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recommendations! Published in 2020 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.0c00550

Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disorder, the pathogenesis of which is closely linked to the misfolding and aggregation of the neuronal protein α-Synuclein (A-Syn). Numerous molecules that inhibit/modulate the pathogenic aggregation… read more here.

Keywords: fibrillation; bbb permeability; gold nanoclusters; synuclein fibrillation ... See more keywords

Discerning Modulation of α-Synuclein Amyloid Assembly by α-Crystallin.

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recommendations! Published in 2023 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.3c00052

Abstract: Altered protein folding leading to the formation of structured aggregates such as amyloid fibrils has gained significant attention due to its association with neurodegenerative diseases. α-Synuclein, a small intrinsically disordered protein, gets transformed into amyloid… read more here.

Keywords: crystallin; modulation synuclein; chaperone like; synuclein amyloid ... See more keywords

Modulation of α-synuclein AGE-based cytotoxic aggregation by zinc oxide nanoparticles: a potential therapeutic approach

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recommendations! Published in 2025 at "New Journal of Chemistry"

DOI: 10.1039/d5nj03165f

Abstract: The non-enzymatic posttranslational glycation, resulting in advanced glycation end product (AGE) formation, is involved in various central nervous system pathologies like Parkinson’s and Alzheimer’s diseases. α-Synuclein (αS) containing lysine residues... read more here.

Keywords: age; age based; based cytotoxic; cytotoxic aggregation ... See more keywords

Modulation of α-synuclein aggregation amid diverse environmental perturbation

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recommendations! Published in 2024 at "eLife"

DOI: 10.1101/2023.10.19.563053

Abstract: Intrinsically disordered protein α-Synuclein (αS) is implicated in Parkinson’s disease due to its aberrant aggregation propensity. In a bid to identify the traits of its aggregation, here we computationally simulate the multi-chain association process of… read more here.

Keywords: diverse environmental; aggregation; modulation synuclein; synuclein aggregation ... See more keywords