Modulation of α-Synuclein Fibrillation by Ultrasmall and Biocompatible Gold Nanoclusters.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00550
Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disorder, the pathogenesis of which is closely linked to the misfolding and aggregation of the neuronal protein α-Synuclein (A-Syn). Numerous molecules that inhibit/modulate the pathogenic aggregation… read more here.
Keywords: fibrillation; bbb permeability; gold nanoclusters; synuclein fibrillation ... See more keywords
Discerning Modulation of α-Synuclein Amyloid Assembly by α-Crystallin.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00052
Abstract: Altered protein folding leading to the formation of structured aggregates such as amyloid fibrils has gained significant attention due to its association with neurodegenerative diseases. α-Synuclein, a small intrinsically disordered protein, gets transformed into amyloid… read more here.
Keywords: crystallin; modulation synuclein; chaperone like; synuclein amyloid ... See more keywords