Frequency Modulation of Transcriptional Bursting Enables Sensitive and Rapid Gene Regulation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.01.012
Abstract: Gene regulation is a complex non-equilibrium process. Here, we show that quantitating the temporal regulation of key gene states (transcriptionally inactive, active, and refractory) provides a parsimonious framework for analyzing gene regulation. Our theory makes… read more here.
Keywords: gene regulation; frequency modulation; gene; modulation transcriptional ... See more keywords
Modulation of H-NS transcriptional silencing by magnesium
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky387
Abstract: Abstract The bacterial histone-like protein H-NS silences AT-rich DNA, binding DNA as ‘stiffened’ filaments or ‘bridged’ intrastrand loops. The switch between these modes has been suggested to depend on the concentration of divalent cations, in… read more here.
Keywords: transcriptional silencing; dna; silencing; silencing magnesium ... See more keywords