Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential
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DOI: 10.3390/ph10020035
Abstract: Two transient receptor potential (TRP) channels—TRPA1 and TRPV3—are post-translationally hydroxylated, resulting in oxygen-dependent regulation of channel activity. The enzymes responsible are the HIF prolyl hydroxylases (PHDs) and the asparaginyl hydroxylase factor inhibiting HIF (FIH). The… read more here.
Keywords: hydroxylation; channel activity; trp channel; modulation trp ... See more keywords