Use of CFTR modulators in special populations, part 3: Solid organ transplant.
Sign Up to like & getrecommendations! Published in 2023 at "Pediatric pulmonology"
DOI: 10.1002/ppul.26396
Abstract: BACKGROUND Solid organ transplant (SOT) recipients with cystic fibrosis (CF) may benefit from the pulmonary and extrapulmonary benefits associated with CF transmembrane conductance regulator modulators. Nevertheless, evolution of modulator safety and efficacy data prompts consideration.… read more here.
Keywords: modulator; lung; transplant recipients; organ transplant ... See more keywords
Design and Analysis of an Ultra-Low-Power Second-Order Asynchronous Delta–Sigma Modulator
Sign Up to like & getrecommendations! Published in 2017 at "Circuits, Systems, and Signal Processing"
DOI: 10.1007/s00034-017-0658-7
Abstract: In this paper, a second-order asynchronous delta–sigma modulator is proposed based on the active-RC integrators. The operational transconductance amplifiers used in the integrators are improved by employing a class-AB structure with bulk-driven input drivers and… read more here.
Keywords: order; asynchronous delta; delta sigma; second order ... See more keywords
Design-to-testing: a low-power, 1.25 GHz, single-bit single-loop continuous-time $$\Delta \Sigma$$ΔΣ modulator with 15 MHz bandwidth and 60 dB dynamic range
Sign Up to like & getrecommendations! Published in 2017 at "Analog Integrated Circuits and Signal Processing"
DOI: 10.1007/s10470-016-0865-3
Abstract: Continuous-time Delta-Sigma (CT-$$\Delta \Sigma$$ΔΣ) analog-to-digital converters have been extensively investigated for their use in wireless receivers to achieve conversion bandwidths >15 MHz and higher resolution of 10–14 bits. This paper presents the complete design-to-testing tutorial of a… read more here.
Keywords: delta sigma; sigma; time delta; continuous time ... See more keywords
Design of A 1-V 3rd-order 1-bit Σ-Δ modulator with inverter-based static–dynamic hybrid structure amplifiers
Sign Up to like & getrecommendations! Published in 2019 at "Analog Integrated Circuits and Signal Processing"
DOI: 10.1007/s10470-019-01532-9
Abstract: A 1-V 3rd-order 1-bit discrete time (DT) Σ-Δ modulator is designed and implemented in a 40-nm CMOS technology. With the input feed forward coefficient optimized, the output swings of the integrators are minimized. The bootstrapped… read more here.
Keywords: order bit; order; based static; 3rd order ... See more keywords
Ultra-compact low loss electro-optical nanobeam cavity modulator embedded photonic crystal
Sign Up to like & getrecommendations! Published in 2019 at "Optical and Quantum Electronics"
DOI: 10.1007/s11082-019-1835-7
Abstract: In this paper, a hybrid electro-optical modulator based on a one-dimensional photonic crystal nanobeam cavity is proposed. The main component of the cavity builder is the indium–tin–oxide that is a transparent conductive oxide. The proposed… read more here.
Keywords: modulator; nanobeam cavity; cavity; photonic crystal ... See more keywords
A Compact Graphene Modulator Based on Localized Surface Plasmon Resonance with a Chain of Metal Disks
Sign Up to like & getrecommendations! Published in 2019 at "Plasmonics"
DOI: 10.1007/s11468-019-00995-w
Abstract: Most graphene electro-optic modulators based on the electro-refractive modulation are composed of Mach-Zehnder interferometer or microring resonator structures and have a relative compact size comparing with dielectric ones. To further shrink the footprint, we use… read more here.
Keywords: graphene; graphene modulator; surface plasmon; modulator ... See more keywords
A Millimeter-Wave Generation Scheme Based on Frequency Octupling Using LiNbO3 Mach–Zehnder Modulator
Sign Up to like & getrecommendations! Published in 2019 at "National Academy Science Letters"
DOI: 10.1007/s40009-018-0766-3
Abstract: AbstractThe proposed frequency octupling method demonstrates the generation of millimeter-wave (mmw) signal using LiNbO3 Mach–Zehnder modulator based on frequency octupling. The optical carrier suppression modulation scheme is employed to produce a mmw signal of 80 GHz.… read more here.
Keywords: generation; scheme; modulator; frequency ... See more keywords
Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological Reports"
DOI: 10.1007/s43440-021-00352-x
Abstract: Background Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays one of the hot topics in drug discovery. In particular, allosteric modulators of D2 receptor have been proposed as potential modern therapeutics to treat schizophrenia… read more here.
Keywords: modulator; d2l receptor; allosteric modulation; receptor ... See more keywords
A small molecule UPR modulator for diabetes identified by high throughput screening
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.05.018
Abstract: Abstract Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding… read more here.
Keywords: molecule; small molecule; high throughput; modulator ... See more keywords
Anti‐inflammatory actions of Caesalpinin M2 in experimental colitis as a selective glucocoricoid receptor modulator
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.02.003
Abstract: Graphical abstract Figure. No Caption available. Abstract Although repression of inflammatory gene expression makes glucocorticoids (GCs) powerful anti‐inflammatory agents, side effects limit usage and drive the search for improved glucocorticoid receptor (GR) ligands. It has… read more here.
Keywords: anti inflammatory; inflammatory actions; colitis; receptor ... See more keywords
Cytokines and growth factors in a biologic product obtained from patients' urine as immune-modulators to treat autoimmune and allergic diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Cytokine"
DOI: 10.1016/j.cyto.2021.155427
Abstract: At "Instituto de Alergias y Autoinmunidad Dr. Maximiliano Ruiz Castañeda, A.C." in Mexico City, a non-traditional health care center focused on the treatment of autoimmune and allergic diseases using personalized medicine, an alternative treatment referred… read more here.
Keywords: immune modulator; treatment; growth factors; modulator ... See more keywords