Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor.
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DOI: 10.1021/acs.jmedchem.1c00029
Abstract: The identification of LSN3318839, a positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R), is described. LSN3318839 increases the potency and efficacy of the weak metabolite GLP-1(9-36)NH2 to become a full agonist at the GLP-1R… read more here.
Keywords: allosteric modulator; glucagon like; glp; modulator glucagon ... See more keywords