NAE modulators: A potential therapy for gastric carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114156
Abstract: Neural precursor cell expressed developmentally downregulated protein-8 (NEDD8) is a ubiquitin-like protein, which activates an important post-translational modification process: neddylation, thereby regulating the stability and degradation of various proteins related to multiple physiological processes. And… read more here.
Keywords: modulators potential; gastric carcinoma; anti tumor; nae modulators ... See more keywords
KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Current Neuropharmacology"
DOI: 10.2174/1570159x15666170630164226
Abstract: Background The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such as T- and B-lymphocytes, mast cells, macrophages and microglia, but also found in dedifferentiated vascular smooth muscle cells,… read more here.
Keywords: channel modulators; kca3 channel; compounds glioblastoma; therapeutic compounds ... See more keywords
Leptin-Activity Modulators and Their Potential Pharmaceutical Applications
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11071045
Abstract: Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is implicated in a wide range of biological functions that control different processes, such as the regulation of body weight and energy expenditure,… read more here.
Keywords: leptin; leptin receptor; activity modulators; leptin activity ... See more keywords