A statistical physics approach for disease module detection
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DOI: 10.1101/gr.276690.122
Abstract: Extensive evidence indicates that the pathobiological processes of a complex disease are associated with perturbation within specific disease neighborhoods of the human protein-protein interaction (PPI) network (a.k.a. the interactome), often referred to as the disease… read more here.
Keywords: physics; disease; disease module; module detection ... See more keywords
MDSN: A Module Detection Method for Identifying High-Order Epistatic Interactions
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DOI: 10.3390/genes13122403
Abstract: Epistatic interactions are referred to as SNPs (single nucleotide polymorphisms) that affect disease development and trait expression nonlinearly, and hence identifying epistatic interactions plays a great role in explaining the pathogenesis and genetic heterogeneity of… read more here.
Keywords: epistatic interactions; high order; module detection; order ... See more keywords