Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism.
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DOI: 10.1016/j.bbrc.2019.02.131
Abstract: The antibiotic moenomycin A is a phosphoglycerate derivative with a C25-moenocinyl chain and a branched oligosaccharide. Formation of the C25-chain is catalyzed by the enzyme MoeN5 with geranyl pyrophosphate (GPP) and the sugar-linked 2-Z,E-farnesyl-3-phosphoglycerate (FPG)… read more here.
Keywords: mechanism; moen5 substrate; structures moen5; site ... See more keywords