Negative allosteric modulators of NMDA receptors with GluN2B subunit: Alanine‐derived benzoxazolone bioisosteres of 2‐methyl‐3‐benzazepine‐1,7‐diols
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200177
Abstract: Inspired by besonprodil, the phenol of potent negative allosteric modulators of GluN2B‐N‐methyl‐d‐aspartate (NMDA) receptors was replaced by a benzoxazolone system. To increase the similarity to the lead compounds, an additional methyl moiety was installed in… read more here.
Keywords: nmda receptors; allosteric modulators; moiety; benzoxazolone ... See more keywords
Synthesis of Monovalent N‐Acetylgalactosamine Phosphoramidite for Liver‐Targeting Oligonucleotides
Sign Up to like & getrecommendations! Published in 2019 at "Current Protocols in Nucleic Acid Chemistry"
DOI: 10.1002/cpnc.99
Abstract: Ligand‐targeted drug delivery (LTDD) has emerged as an attractive option in the field of oligonucleotide drugs following the great success of N‐acetylgalactosamine (GalNAc)–conjugated siRNA and antisense oligonucleotides. GalNAc is a well‐known ligand of the asialoglycoprotein… read more here.
Keywords: acetylgalactosamine; galnac; moiety; monovalent ... See more keywords
Structural Diversification of Light-Metal Coordination Polymers Using 4-(Methylsulfonyl)benzoate with a Charge-Polarized Neutral Methylsulfonyl Coordination Moiety
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DOI: 10.1002/ejic.201700627
Abstract: We attempted the synthesis and crystallographic characterization of light-metal coordination polymers (CPs) using a 4-(methylsulfonyl)benzoate (msbza–) ligand with a charge-polarized neutral methylsulfonyl coordination moiety, in order to diversify the limited structures of light-metal CPs, as… read more here.
Keywords: coordination; neutral methylsulfonyl; moiety; methylsulfonyl coordination ... See more keywords
Click regulation of cyclodextrin primary face for the preparation of novel chiral stationary phases
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201800418
Abstract: In this study, a series of novel CD chiral stationary phases were fabricated by immobilization of mono‐6A‐deoxy‐N3‐cyclodextrin onto silica surfaces followed by click regulation of CD primary face with 4‐pentynoic acid (acidic moiety), 2‐propynylamine (alkaline… read more here.
Keywords: novel chiral; primary face; chiral stationary; moiety ... See more keywords
Synthesis, thermal, spectral, antimicrobial and cytotoxicity profile of the Schiff bases bearing pyrazolone moiety and their Cu(II) complexes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-018-7681-1
Abstract: A series of Schiff bases resulted in the [1 + 1] condensation of 8-alkyl-2-hydroxy-tricyclo[7.3.1.02.7]-tridecan-13-one with the 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, and their complexes CuL(CH3COO)2·nH2O were synthesized. The compounds were characterized by microanalytical, ESI–MS, NMR, IR, electronic and EPR spectra. Based… read more here.
Keywords: schiff; schiff bases; synthesis thermal; spectral antimicrobial ... See more keywords
Mono-C,O-chelated bromo- and triflatosilanes with an amino acid moiety: salts or covalently bonded complexes?
Sign Up to like & getrecommendations! Published in 2019 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-019-2429-z
Abstract: Derivatives of the amino acids sarcosine and proline – triflates TsN(Me)CH2C(O)N(Me)-CH2SiMe2OTf and Ns–Pro–N(Me)CH2SiMe2OTf (Ns is 4-NO2C6H4SO2) – were synthesized by the reaction of trimethylsilyl triflate with halosilanes prepared previously. Bromide NsNHCH(Me)C(O)N(Me)CH2SiMe2Br was synthesized by the… read more here.
Keywords: tsn ch2c; mono chelated; triflatosilanes amino; moiety ... See more keywords
Partial sequence isolation of DXS and AOS genes and gene expression analysis of terpenoids and pyrethrin biosynthetic pathway of Chrysanthemum cinerariaefolium under abiotic elicitation
Sign Up to like & getrecommendations! Published in 2020 at "Acta Physiologiae Plantarum"
DOI: 10.1007/s11738-020-3019-2
Abstract: One of the most important issues in crop production is the use of agrochemicals. The use of synthetic or manufactured chemicals on crops has made a frightening image of health problems. A concern about chemical… read more here.
Keywords: gene expression; chrysanthemum cinerariaefolium; moiety; gene ... See more keywords
Synthesis, in vitro evaluation and molecular docking of new pyrazole derivatives bearing 1,5,10,10a-tetrahydrobenzo[g]quinoline-3-carbonitrile moiety as potent antibacterial agents
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-020-02086-8
Abstract: In the current study, a new series of pyrazole derivatives 4a – d , 5a – d and 6a – d possessing 1,5,10,10a-tetrahydrobenzo[ g ]quinoline-3-carbonitrile moiety were synthesized by treating chalcones ( 3a – d… read more here.
Keywords: pyrazole derivatives; moiety; quinoline carbonitrile; 10a tetrahydrobenzo ... See more keywords
Coordination and catalytic chemistry of phosphinoferrocene carboxamides
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DOI: 10.1016/j.ccr.2017.10.003
Abstract: Abstract Amidation reactions of ferrocene phosphinocarboxylic acids and various simple or functional amines provide access to a range of specific metalloligands combining the soft phosphine moiety with easily changeable, hard-donor amide substituents. Compounds of this… read more here.
Keywords: phosphinoferrocene carboxamides; chemistry; coordination catalytic; moiety ... See more keywords
Dynamics of reactions inhibiting epitaxial growth of Si(100) surfaces via interaction with hydrogen chloride
Sign Up to like & getrecommendations! Published in 2018 at "Computational Materials Science"
DOI: 10.1016/j.commatsci.2018.08.037
Abstract: Abstract The dynamics of reactions of HCl at growing Si(100) surfaces was investigated through computational methods, using clusters of different sizes and shapes. The analysis was conducted through Gaussian09 at the B3LYP/6-31G(d,p) level. It was… read more here.
Keywords: dynamics reactions; surface; moiety; sicl2 moiety ... See more keywords
Influence of functional moiety in lupane-type triterpenoids in BACE1 inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2019.107101
Abstract: Lupane-type triterpenoids have shown a potential effect against neurodegenerative disorders. Alzheimer's disease, one of the common neurodegenerative disease, is evident by the accumulation of amyloid-beta (Aβ) plaque in the extracellular regions of the brain. β-site… read more here.
Keywords: moiety; type triterpenoids; bace1; lupane type ... See more keywords