Negative allosteric modulators of NMDA receptors with GluN2B subunit: Alanine‐derived benzoxazolone bioisosteres of 2‐methyl‐3‐benzazepine‐1,7‐diols
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200177
Abstract: Inspired by besonprodil, the phenol of potent negative allosteric modulators of GluN2B‐N‐methyl‐d‐aspartate (NMDA) receptors was replaced by a benzoxazolone system. To increase the similarity to the lead compounds, an additional methyl moiety was installed in… read more here.
Keywords: nmda receptors; allosteric modulators; moiety; benzoxazolone ... See more keywords
Late‐Stage Diversification of Pyrazoles as Antileishmanial Agents
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202400028
Abstract: N‐Pyrazolylcarboxamides and N‐pyrazolylureas represent promising lead compounds for the development of novel antileishmanial drugs. Herein, we report the late‐stage diversification of 3‐bromopyrazoles 10 A/B and 14 A by Pd‐catalyzed Sonogashira and Suzuki‐Miyaura cross coupling reactions. The electron‐withdrawing… read more here.
Keywords: position; late stage; moiety; stage diversification ... See more keywords
Synthesis of Monovalent N‐Acetylgalactosamine Phosphoramidite for Liver‐Targeting Oligonucleotides
Sign Up to like & getrecommendations! Published in 2019 at "Current Protocols in Nucleic Acid Chemistry"
DOI: 10.1002/cpnc.99
Abstract: Ligand‐targeted drug delivery (LTDD) has emerged as an attractive option in the field of oligonucleotide drugs following the great success of N‐acetylgalactosamine (GalNAc)–conjugated siRNA and antisense oligonucleotides. GalNAc is a well‐known ligand of the asialoglycoprotein… read more here.
Keywords: acetylgalactosamine; galnac; moiety; monovalent ... See more keywords
Structural Diversification of Light-Metal Coordination Polymers Using 4-(Methylsulfonyl)benzoate with a Charge-Polarized Neutral Methylsulfonyl Coordination Moiety
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Inorganic Chemistry"
DOI: 10.1002/ejic.201700627
Abstract: We attempted the synthesis and crystallographic characterization of light-metal coordination polymers (CPs) using a 4-(methylsulfonyl)benzoate (msbza–) ligand with a charge-polarized neutral methylsulfonyl coordination moiety, in order to diversify the limited structures of light-metal CPs, as… read more here.
Keywords: coordination; neutral methylsulfonyl; moiety; methylsulfonyl coordination ... See more keywords
Click regulation of cyclodextrin primary face for the preparation of novel chiral stationary phases
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201800418
Abstract: In this study, a series of novel CD chiral stationary phases were fabricated by immobilization of mono‐6A‐deoxy‐N3‐cyclodextrin onto silica surfaces followed by click regulation of CD primary face with 4‐pentynoic acid (acidic moiety), 2‐propynylamine (alkaline… read more here.
Keywords: novel chiral; primary face; chiral stationary; moiety ... See more keywords
New Polymeric Acceptors Based on Benzo[1,2-b:4,5-b'] Difuran Moiety for Efficient All-Polymer Solar Cells.
Sign Up to like & getrecommendations! Published in 2024 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202400787
Abstract: In order to realize high-performance bulk-heterojunction (BHJ) all-polymer solar cells, achieving appropriate aggregation and moderate miscibility of the polymer blends is one critical factor. Herein, this study designs and synthesizes two new polymer acceptors (PAs),… read more here.
Keywords: solar cells; polymer solar; polymer; benzo difuran ... See more keywords
Universal Single Atom Engineering Enhances Coulombic Efficiency of Ion Storage in Carbon Materials.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202500909
Abstract: Metal single atoms are widely used to optimize the microstructure of carbon materials to improve their ion storage capacity and rate performance, but the impact on another key parameter, Coulombic efficiency (CE), is not sufficiently… read more here.
Keywords: carbon; storage; ion storage; carbon materials ... See more keywords
Synthesis, thermal, spectral, antimicrobial and cytotoxicity profile of the Schiff bases bearing pyrazolone moiety and their Cu(II) complexes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-018-7681-1
Abstract: A series of Schiff bases resulted in the [1 + 1] condensation of 8-alkyl-2-hydroxy-tricyclo[7.3.1.02.7]-tridecan-13-one with the 4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, and their complexes CuL(CH3COO)2·nH2O were synthesized. The compounds were characterized by microanalytical, ESI–MS, NMR, IR, electronic and EPR spectra. Based… read more here.
Keywords: schiff; schiff bases; synthesis thermal; spectral antimicrobial ... See more keywords
Mono-C,O-chelated bromo- and triflatosilanes with an amino acid moiety: salts or covalently bonded complexes?
Sign Up to like & getrecommendations! Published in 2019 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-019-2429-z
Abstract: Derivatives of the amino acids sarcosine and proline – triflates TsN(Me)CH2C(O)N(Me)-CH2SiMe2OTf and Ns–Pro–N(Me)CH2SiMe2OTf (Ns is 4-NO2C6H4SO2) – were synthesized by the reaction of trimethylsilyl triflate with halosilanes prepared previously. Bromide NsNHCH(Me)C(O)N(Me)CH2SiMe2Br was synthesized by the… read more here.
Keywords: tsn ch2c; mono chelated; triflatosilanes amino; moiety ... See more keywords
Partial sequence isolation of DXS and AOS genes and gene expression analysis of terpenoids and pyrethrin biosynthetic pathway of Chrysanthemum cinerariaefolium under abiotic elicitation
Sign Up to like & getrecommendations! Published in 2020 at "Acta Physiologiae Plantarum"
DOI: 10.1007/s11738-020-3019-2
Abstract: One of the most important issues in crop production is the use of agrochemicals. The use of synthetic or manufactured chemicals on crops has made a frightening image of health problems. A concern about chemical… read more here.
Keywords: gene expression; chrysanthemum cinerariaefolium; moiety; gene ... See more keywords
Synthesis, in vitro evaluation and molecular docking of new pyrazole derivatives bearing 1,5,10,10a-tetrahydrobenzo[g]quinoline-3-carbonitrile moiety as potent antibacterial agents
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-020-02086-8
Abstract: In the current study, a new series of pyrazole derivatives 4a – d , 5a – d and 6a – d possessing 1,5,10,10a-tetrahydrobenzo[ g ]quinoline-3-carbonitrile moiety were synthesized by treating chalcones ( 3a – d… read more here.
Keywords: pyrazole derivatives; moiety; quinoline carbonitrile; 10a tetrahydrobenzo ... See more keywords