An effective method for bisphosphonate moiety inserting into O–H bond of carboxylic acids by Cu (II) catalyst
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.12.038
Abstract: Abstract In this study we developed a novel copper-catalyzed O–H insertion of tetraethyl diphosphonodiazomethane into carboxylic acids, providing a simple method to link bisphosphonates to compounds containing carboxyl group. Moreover, a novel bone-targeting prodrug of… read more here.
Keywords: moiety inserting; inserting bond; carboxylic acids; effective method ... See more keywords