Small RNA sequencing in hypoxic naked mole‐rat hearts suggests microRNA regulation of RNA‐ and translation‐related processes
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14499
Abstract: The naked mole‐rat (Heterocephalus glaber) regularly endures intermittent periods of hypoxia in its burrows, surviving in part due to metabolic rate depression (MRD)—a strategy of conserving cellular resources by downregulating nonessential gene expression and reorganizing cellular… read more here.
Keywords: rna sequencing; naked mole; translation related; small rna ... See more keywords
Muscle architecture and muscle fibre type composition in the forelimb of two African mole‐rat species, Bathyergus suillus and Heterocephalus glaber
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Morphology"
DOI: 10.1002/jmor.21557
Abstract: The scratch‐digging Cape dune mole‐rat (Bathyergus suillus), and the chisel‐toothed digging naked mole‐rat (Heterocephalus glaber) are African mole‐rats that differ in their digging strategy. The aim of this study was to determine if these behavioural… read more here.
Keywords: glaber; type composition; fibre type; muscle ... See more keywords
Atg5-mediated autophagy controls apoptosis/anoikis via p53/Rb pathway in naked mole-rat fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.083
Abstract: The naked mole-rat (NMR, Heterocephalus glaber) is the longest-living known rodent species, with a maximum lifespan of over 30 years. NMRs exhibit negligible senescence, exceptional resistance to cancer, and high basal autophagy activity compared with… read more here.
Keywords: apoptosis; mole rat; naked mole; apoptosis anoikis ... See more keywords
Effects of dexamethasone and acetylsalicylic acid on inflammation caused by Complete Freund's adjuvant in the naked mole rat (Heterocephalus glaber)
Sign Up to like & getrecommendations! Published in 2022 at "Heliyon"
DOI: 10.1016/j.heliyon.2022.e08920
Abstract: The naked mole rat (NMR) is a fossorial rodent that has been observed to have a unique nociceptive system in comparison to others. In this study, we explored on characterization of chronic inflammation in the… read more here.
Keywords: naked mole; acetylsalicylic acid; complete freund; dexamethasone acetylsalicylic ... See more keywords
Unraveling the gut microbiome of the long-lived naked mole-rat
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10287-0
Abstract: The naked mole-rat (Heterocephalus glaber) is a subterranean mouse-sized African mammal that shows astonishingly few age-related degenerative changes and seems to not be affected by cancer. These features make this wild rodent an excellent model… read more here.
Keywords: naked mole; gut microbiome; biology; mole rat ... See more keywords
Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax – a liver transcriptomics approach
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13905-z
Abstract: The blind subterranean mole rat Spalax shows a remarkable tolerance to hypoxia, cancer-resistance and longevity. Unravelling the genomic basis of these adaptations will be important for biomedical applications. RNA-Seq gene expression data were obtained from… read more here.
Keywords: spalax; rat spalax; tolerance; liver ... See more keywords
Unprovoked Stabilization and Nuclear Accumulation of the Naked Mole-Rat p53 Protein
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64009-0
Abstract: The naked mole-rat is a subterranean rodent, approximately the size of a mouse, renowned for its exceptional longevity (>30 years) and remarkable resistance to cancer. To explore putative mechanisms underlying the cancer resistance of the… read more here.
Keywords: naked mole; p53 protein; mole rat;
Pre- and postcopulatory competition affect testes mass and organization differently in two monophyletic mole-rat species, Georychus capensis and Fukomys damarensis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Mammalogy"
DOI: 10.1093/jmammal/gyad021
Abstract: Sperm competition results from postcopulatory continuation of male–male competition for paternity. The level of sperm competition is predicted to be highest in species with greater polyandry and weakest in monogamous pairs. Sperm competition levels can… read more here.
Keywords: pre postcopulatory; sperm competition; competition; testes mass ... See more keywords
Daily and Seasonal Feeding Activity of the Greater Mole-Rat (Spalax microphtalmus, Rodentia, Spalacidae)
Sign Up to like & getrecommendations! Published in 2019 at "Biology Bulletin"
DOI: 10.1134/s1062359019090012
Abstract: The activity of the greater mole-rat was studied using a new technique. New data have been obtained on the characteristics of the daily and seasonal underground life of mole-rats in an isolated population in Mordovia.… read more here.
Keywords: greater mole; mole rat; activity; daily seasonal ... See more keywords
The anti-tumorigenic activity of A2M—A lesson from the naked mole-rat
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0189514
Abstract: Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute… read more here.
Keywords: tumorigenic activity; anti tumorigenic; mole rat; naked mole ... See more keywords
First Report of Gastrointestinal Parasites from Ansell's Mole-Rat (Fukomys anselli) in Zambia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Parasitology"
DOI: 10.1645/17-123
Abstract: Abstract The endoparasite fauna of Ansell's mole-rat, Fukomys anselli (Burda, Zima, Scharff, Macholán and Kawalika) (Rodentia, Bathyergidae), was studied for the first time near Lusaka, Zambia. We recovered 7 endoparasite taxa including 5 nematodes (Hexametra… read more here.
Keywords: ansell mole; fukomys anselli; rat fukomys; mole rat ... See more keywords