Integrated molecular profiling of patient-derived ovarian cancer models identifies clinically relevant signatures and tumor vulnerabilities.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of cancer"
DOI: 10.1002/ijc.33983
Abstract: High-grade serous ovarian carcinoma (HGSOC) is a highly aggressive and intractable neoplasm, mainly because of its rapid dissemination into the abdominal cavity, a process that is favored by tumor-associated peritoneal ascites. The precise molecular alterations… read more here.
Keywords: tumor; cancer; patient; molecular alterations ... See more keywords
Molecular alterations of mitochondrial D‐loop in oral leukoplakia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28668
Abstract: Over the years, numerous studies proposed a crucial role of mutations of nuclear DNA in the carcinogenesis process. Of late, many researchers suppose that alterations of mitochondrial DNA should not be excepted from this analysis.… read more here.
Keywords: biochemistry; oral leukoplakia; loop oral; mitochondrial loop ... See more keywords
Targetable molecular alterations in congenital glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03377-8
Abstract: Introduction Congenital glioblastomas (cGBMs) are uncommon tumors presenting in early infancy, variably defined as diagnosed at birth or at age less than 3 months by strict criteria, or more loosely, as occurring in very young children… read more here.
Keywords: cgbms; congenital glioblastoma; age; alterations congenital ... See more keywords
Precision medicine in breast cancer: From clinical trials to clinical practice.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2021.102223
Abstract: INTRODUCTION Breast cancer (BC) is the most common cancer in women and, despite the undeniable improvements in the outcome of these patients obtained in the last decade, the discovery and the validation of new actionable… read more here.
Keywords: medicine; evidence; breast cancer; molecular alterations ... See more keywords
Jagged-1 induced molecular alterations in HPV associated invasive squamous cell and adenocarcinoma of the human uterine cervix
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27699-1
Abstract: The majority of cervical cancer (CC) cases are attributable to HPV infection. Altered Notch pathway signals and HPV are believed to modify clinicopathogenesis of CC, however, the involvement of each molecular player and its mechanism… read more here.
Keywords: jag1; induced molecular; molecular alterations; hpv associated ... See more keywords
Molecular alterations in basal cell carcinoma subtypes
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-92592-3
Abstract: A number of genes have been implicated in the pathogenesis of BCC in addition to the Hedgehog pathway, which is known to drive the initiation of this tumour. We performed in-depth analysis of 13 BCC-related… read more here.
Keywords: alterations basal; cell carcinoma; basal cell; bcc ... See more keywords
Druggable molecular alterations in bile duct cancer: potential and current therapeutic applications in clinical trials
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2021.1964470
Abstract: ABSTRACT Introduction: Cholangiocarcinomas (CCA) are rare tumors that are associated with a variety of molecular alterations. Many of these alterations are now actionable using drugs currently in development, and CCA may be a perfect example… read more here.
Keywords: development cca; oncology; molecular alterations; clinical trials ... See more keywords
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqy004
Abstract: Objectives Multinodular goiter (MNG) and well-differentiated thyroid carcinoma (WDTC) are emerging phenotypes of DICER1 syndrome. Methods Histologic and molecular findings of botryoid-type embryonal rhabdomyosarcoma (bERMS) and thyroid nodules from a 12-year-old DICER1 mutation carrier (p.Arg1060Ilefs*7)… read more here.
Keywords: dicer1 syndrome; histologic molecular; case; multinodular goiter ... See more keywords
Wedding of Molecular Alterations and Immune Checkpoint Blockade: Genomics as a Matchmaker.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the National Cancer Institute"
DOI: 10.1093/jnci/djab067
Abstract: The development of checkpoint blockade immunotherapy has transformed the medical oncology armamentarium. But, despite its favorable impact on clinical outcomes, immunotherapy benefits only a subset of patients, and a substantial proportion of these individuals eventually… read more here.
Keywords: checkpoint blockade; wedding molecular; molecular alterations; checkpoint ... See more keywords
Voxel-wise radiogenomic mapping of tumor location with key molecular alterations in patients with glioma
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noy134
Abstract: Background This study aims to evaluate the impact of tumor location on key molecular alterations on a single voxel level in patients with newly diagnosed glioma. Methods A consecutive series of n = 237 patients… read more here.
Keywords: location; location key; tumor location; key molecular ... See more keywords
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.146196
Abstract: Development of primary liver cancer is a multistage process. Detailed understanding of sequential epigenetic alterations is largely missing. Here, we performed Infinium Human Methylation 450k BeadChips and RNA-Seq analyses for genome-wide methylome and transcriptome profiling… read more here.
Keywords: epigenetic modifications; precede molecular; modifications precede; alterations drive ... See more keywords