Molecular Basis of Ubiquitination Catalyzed by the Bacterial Transglutaminase MavC
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.202000871
Abstract: Abstract The Legionella pneumophila effector MavC is a transglutaminase that carries out atypical ubiquitination of the host ubiquitin (Ub)‐conjugation enzyme UBE2N by catalyzing the formation of an isopeptide bond between Gln40Ub and Lys92UBE2N, which leads… read more here.
Keywords: mavc; transglutaminase; molecular basis; basis ubiquitination ... See more keywords
Recent advances in the design of choline kinase α inhibitors and the molecular basis of their inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Research Reviews"
DOI: 10.1002/med.21746
Abstract: Upregulated choline metabolism, characterized by an increase in phosphocholine (PCho), is a hallmark of oncogenesis and tumor progression. Choline kinase (ChoK), the enzyme responsible for PCho synthesis, has consequently become a promising drug target for… read more here.
Keywords: chok inhibitors; molecular basis; recent advances; choline kinase ... See more keywords
Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo Using Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8559-3_13
Abstract: The C. elegans nematode is a powerful genetic tool for the study of aging, developmental biology, and neurodegenerative diseases. They are a small and simple model, but its well-known genome and presence of many human… read more here.
Keywords: molecular basis; biology; investigate molecular; basis progranulin ... See more keywords
Molecular Basis and Regulation of Store-Operated Calcium Entry.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_17
Abstract: Store-operated Ca2+ entry (SOCE) is a ubiquitous mechanism for Ca2+ influx in mammalian cells with important physiological implications. Since the discovery of SOCE more than three decades ago, the mechanism that communicates the information about… read more here.
Keywords: store operated; molecular basis; basis regulation; ca2 ... See more keywords
The genetic and molecular basis of crop height based on a rice model
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DOI: 10.1007/s00425-017-2798-1
Abstract: AbstractMain conclusionThis review presents genetic and molecular basis of crop height using a rice crop model. Height is controlled by multiple genes with potential to be manipulated through breeding strategies to improve productivity. Height is… read more here.
Keywords: genetic molecular; rice; molecular basis; model ... See more keywords
Molecular basis of triterpene-based chemophenetics in ferns
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DOI: 10.1007/s00425-020-03369-3
Abstract: Main conclusion A hypothesis that squalene cyclase genes are widely distributed throughout ferns was proposed. We successfully isolated a squalene cyclase pseudogene from a fern from which no triterpene hydrocarbons were detected Abstract Ferns are… read more here.
Keywords: triterpene based; basis triterpene; triterpene; molecular basis ... See more keywords
Molecular Basis of Opioid Action: From Structures to New Leads
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DOI: 10.1016/j.biopsych.2019.08.028
Abstract: Since the isolation of morphine from the opium poppy over 200 years ago, the molecular basis of opioid action has remained the subject of intense inquiry. The identification of specific receptors responsible for opioid function… read more here.
Keywords: opioid action; molecular basis; basis opioid; action structures ... See more keywords
Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of DNA Unwinding during Bacterial Conjugation
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DOI: 10.1016/j.cell.2017.04.010
Abstract: Summary Relaxases play essential roles in conjugation, the main process by which bacteria exchange genetic material, notably antibiotic resistance genes. They are bifunctional enzymes containing a trans-esterase activity, which is responsible for nicking the DNA… read more here.
Keywords: conjugation; molecular basis; cryo structure; dna ... See more keywords
Molecular basis for the evolved instability of a human G-protein coupled receptor
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DOI: 10.1016/j.celrep.2021.110046
Abstract: SUMMARY Membrane proteins are prone to misfolding and degradation. This is particularly true for mammalian forms of the gonadotropin-releasing hormone receptor (GnRHR). Although they function at the plasma membrane, mammalian GnRHRs accumulate within the secretory… read more here.
Keywords: membrane; molecular basis; instability; protein ... See more keywords
Molecular basis for epithelial morphogenesis and ion transport in the Malpighian tubule.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in insect science"
DOI: 10.1016/j.cois.2021.02.001
Abstract: During development, the insect Malpighian tubule undergoes several programmed morphogenetic events that give rise to the tubule's ability to transport ions and water at unparalleled speed. Studies in Diptera, in particular, have greatly increased our… read more here.
Keywords: molecular basis; transport; morphogenesis; basis epithelial ... See more keywords
Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome
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DOI: 10.1016/j.jbior.2017.09.002
Abstract: Mutations that target the ubiquitous process of ribosome assembly paradoxically cause diverse tissue-specific disorders (ribosomopathies) that are often associated with an increased risk of cancer. Ribosomes are the essential macromolecular machines that read the genetic… read more here.
Keywords: diamond syndrome; molecular basis; shwachman diamond; basis human ... See more keywords