Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug-Resistant Cancer Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced functional materials"
DOI: 10.1002/adfm.201701027
Abstract: Multidrug resistance (MDR) resulting from overexpression of P-glycoprotein (Pgp) transporters increases the drug efflux and thereby limits the chemotherapeutic efficacy. It is desirable to administer both an MDR1 gene silencer and a chemotherapeutic agent in… read more here.
Keywords: multidrug; molecular beacon; dox; multidrug resistant ... See more keywords
A novel gold nanoparticles decorated magnetic microbead-based molecular beacon for DNA multiplexing detection by flow cytometry.
Sign Up to like & getrecommendations! Published in 2020 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.02.063
Abstract: Gold nanoparticles-based molecular beacon (Au NPs-MB), due to its extraordinary highly-quenching efficiency for fluorophores, has been extensively investigated and widely used for bioimaging and bioassay. However, apart from irreversible aggregation during the "aging" step, the… read more here.
Keywords: detection; gold nanoparticles; dna; molecular beacon ... See more keywords
Recent Advances in the Molecular Beacon Technology for Live-Cell Single-Molecule Imaging
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101801
Abstract: Summary Nucleic acids, aside from being best known as the carrier of genetic information, are versatile biomaterials for constructing nanoscopic devices for biointerfacing, owing to their unique properties such as specific base pairing and predictable… read more here.
Keywords: molecular beacon; single molecule; recent advances; live cell ... See more keywords
Enzyme-Responsive Double-Locked Photodynamic Molecular Beacon for Targeted Photodynamic Anticancer Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13732
Abstract: An advanced photodynamic molecular beacon (PMB) was designed and synthesized, in which a distyryl boron dipyrromethene (DSBDP)-based photosensitizer and a Black Hole Quencher 3 moiety were connected via two peptide segments containing the sequences PLGVR… read more here.
Keywords: double locked; photodynamic molecular; therapy; tumor ... See more keywords
OWL2: a molecular beacon-based nanostructure for highly selective detection of single-nucleotide variations in folded nucleic acids.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d2nr05590b
Abstract: Hybridization probes have been used in the detection of specific nucleic acids for the last 50 years. Despite the extensive efforts and the great significance, the challenges of the commonly used probes include (1) low… read more here.
Keywords: nucleic acids; nucleotide variations; single nucleotide; detection ... See more keywords
Molecular beacon anchored onto a graphene oxide substrate.
Sign Up to like & getrecommendations! Published in 2017 at "Nanotechnology"
DOI: 10.1088/1361-6528/aa7e50
Abstract: In this article, we report a graphene oxide-based nanosensor incorporating semiconductor quantum dots linked to DNA-aptamers that functions as a 'turn-off' fluorescent nanosensor for detection of low concentrations of analytes. A specific demonstration of this… read more here.
Keywords: graphene oxide; detection; molecular beacon; anchored onto ... See more keywords
A molecular beacon assay for monitoring RNA splicing
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac242
Abstract: Abstract Small molecule targeting of self-splicing RNAs like group I and II introns has been limited in part by the lack of a universal high-throughput screening platform for studies of splicing inhibition and kinetics. Here,… read more here.
Keywords: rna splicing; beacon; monitoring rna; beacon assay ... See more keywords
A CRISPR/molecular beacon hybrid system for live-cell genomic imaging
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky304
Abstract: Abstract The clustered regularly interspersed short palindromic repeat (CRISPR) gene-editing system has been repurposed for live-cell genomic imaging, but existing approaches rely on fluorescent protein reporters, making sensitive and continuous imaging difficult. Here, we present… read more here.
Keywords: system; live cell; molecular beacon; genomic imaging ... See more keywords
Quantitative Detection of miRNA-21 Expression in Tumor Cells and Tissues Based on Molecular Beacon
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Analytical Chemistry"
DOI: 10.1155/2018/3625823
Abstract: As a new tumor marker, the microRNA-21 (miRNA21) level can provide important information for early diagnosis, drug treatment, and prognosis of gastric cancer. With the tool of molecular beacons which can hybridize specifically with target… read more here.
Keywords: detection; molecular beacon; tumor cells; cells tissues ... See more keywords
Molecular Beacon for Detection miRNA-21 as a Biomarker of Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063330
Abstract: Lung cancer (LC) is the leading cause of cancer-related death worldwide. Although the diagnosis and treatment of non-small cell lung cancer (NSCLC), which accounts for approximately 80% of LC cases, have greatly improved in the… read more here.
Keywords: lung cancer; detection; molecular beacon; cancer ... See more keywords