A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Protein & Cell"
DOI: 10.1093/procel/pwac008
Abstract: Emerging evidence suggests that intron-detaining transcripts (IDTs) are a nucleus-detained and polyadenylated mRNA pool for cell to quickly and effectively respond to environmental stimuli and stress. However, the underlying mechanisms of detained intron (DI) splicing… read more here.
Keywords: contributes neurodegeneration; rnps1; molecular brake; spliceosome pausing ... See more keywords
Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01949-4
Abstract: Background Osteopontin (OPN) as a secreted signaling protein is dramatically induced in response to cellular injury and neurodegeneration. Microglial inflammatory responses in the brain are tightly associated with the neuropathologic hallmarks of neurodegenerative disease, but… read more here.
Keywords: brake regulating; response; osteopontin; infection ... See more keywords
Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils
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DOI: 10.1371/journal.pbio.3001794
Abstract: In contrast to molecular changes associated with increased inflammatory responses, little is known about intracellular counter-regulatory mechanisms that control signaling cascades associated with functional responses of neutrophils. Active RHO GTPases are typically considered as effector… read more here.
Keywords: molecular brake; brake actomyosin; actomyosin mediated; effector functions ... See more keywords