Alpha-beta chimeric polypeptide molecular brushes display potent activity against superbugs-methicillin resistant Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2018 at "Science China Materials"
DOI: 10.1007/s40843-018-9351-x
Abstract: 摘要近年来, 以耐甲氧西林金黄色葡萄球菌(MRSA)为代表的“超级细菌”不断被发现和扩散, 已经严重威胁人类健康, 因此, 研制新型、 高效的抗菌剂迫在眉睫. 以宿主防御肽及其模拟物为代表的多肽和聚合物近年来得到广泛关注. 而分子刷作为一类独特的聚合物也显示 了很多特殊的性能. 我们结合前期研究, 首次将两种开环聚合体系即β-内酰胺开环聚合和N-羧基环内酸酐(NCA)开环聚合体系相结合, 以 β多肽为骨架结构进而通过其氨基功能基团进一步引发NCA开环聚合, 合成了侧链具有多个聚赖氨酸的α/β杂化多肽聚合物分子刷. 这种 新型分子刷对多种MRSA菌株均展现出高效的抗菌活性, 甚至优于万古霉素. 通过扫描电子显微镜(SEM)表征, 揭示了α/β杂化多肽聚合物 分子刷的抗菌机理与宿主防御肽类似, 是通过破坏细菌细胞膜的完整性杀菌. α/β杂化多肽聚合物分子刷高度可调的结构特点和高效的抗 菌活性, 显示了其在抗菌研究和应用中的潜力. read more here.
Keywords: molecular brushes; brushes display; polypeptide molecular; beta chimeric ... See more keywords
Synthesis and self-assembly of amphiphilic heterografted molecular brushes prepared by telomerization
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DOI: 10.1016/j.eurpolymj.2020.110080
Abstract: Abstract Heterografted amphiphilic molecular brushes are highly grafted macromolecules with both hydrophilic and hydrophobic side chains attached to the backbone. These macromolecules display a unique combination of properties and can self-assemble in solution to form… read more here.
Keywords: synthesis self; molecular brushes; self assembly; telomerization ... See more keywords
Two-Dimensional Controlled Syntheses of Polypeptide Molecular Brushes via N-Carboxyanhydride Ring-Opening Polymerization and Ring-Opening Metathesis Polymerization
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DOI: 10.1021/acsmacrolett.7b00603
Abstract: Well-defined molecular brushes bearing polypeptides as side chains were prepared by a “grafting through” synthetic strategy with two-dimensional control over the brush molecular architectures. By integrating N-carboxyanhydride ring-opening polymerizations (NCA ROPs) and ring-opening metathesis polymerizations… read more here.
Keywords: molecular brushes; ring opening; polymerization; carboxyanhydride ring ... See more keywords
Compact Peptoid Molecular Brushes for Nanoparticle Stabilization.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c00743
Abstract: Controlling the interfaces and interactions of colloidal nanoparticles (NPs) via tethered molecular moieties is crucial for NP applications in engineered nanomaterials, optics, catalysis, and nanomedicine. Despite a broad range of molecular types explored, there is… read more here.
Keywords: chemistry; brushes nanoparticle; nanoparticle stabilization; molecular brushes ... See more keywords
Facile synthesis of cylindrical molecular brushes via Lewis pair-mediated polymerization
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DOI: 10.1039/c8py01257a
Abstract: We demonstrate the first application of Lewis pair-mediated polymerization (LPP) in the efficient synthesis of cylindrical molecular brushes bearing poly(methyl methacrylate) and polylactone side chains. Poly(N-heterocyclic olefin) (poly(NHO)) as a macroinitiator precursor was firstly prepared… read more here.
Keywords: molecular brushes; polymerization; lewis pair; pair mediated ... See more keywords
A fluorescent sensor for intracellular Zn2+ based on cylindrical molecular brushes of poly(2-oxazoline) through ion-induced emission
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DOI: 10.1039/d0py01054e
Abstract: Mobile divalent zinc, Zn(II), is an essential cofactor involved in mammalian biological processes. To understand the intrinsic action mechanism of mobile zinc, the development of a Zn2+-selective fluorescent probe that can detect mobile zinc via… read more here.
Keywords: molecular brushes; fluorescent sensor; cylindrical molecular; poly oxazoline ... See more keywords
Amphiphilic Molecular Brushes with Regular Polydimethylsiloxane Backbone and Poly-2-isopropyl-2-oxazoline Side Chains. 3. Influence of Grafting Density on Behavior in Organic and Aqueous Solutions
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DOI: 10.3390/polym14235118
Abstract: Regular and irregular molecular brushes with polydimethylsiloxane backbone and poly-2-isopropyl-2-oxazoline side chains have been synthesized. Prepared samples differed strongly in the side chain grafting density, namely, in the ratio of the lengths of spacer between… read more here.
Keywords: aqueous solutions; density; poly isopropyl; side chains ... See more keywords