Redesigning the Molecular Choreography to Prevent Hydroxylation in Germacradien-11-ol Synthase Catalysis
Sign Up to like & getrecommendations! Published in 2021 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c04647
Abstract: Natural sesquiterpene synthases have evolved to make complex terpenoids by quenching reactive carbocations either by proton transfer or by hydroxylation (water capture), depending on their active site. Germacradien-11-ol synthase (Gd11olS) from Streptomyces coelicolor catalyzes the… read more here.
Keywords: molecular choreography; germacradien synthase; germacradien; hydroxylation ... See more keywords
G protein-mediated signal transduction: a molecular choreography of G protein activation after GTP binding
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01903-3
Abstract: A recent report from the Skiniotis group, 1 published in Nature , provides fascinating insight into the molecular choreography underlying a quintessential cellular signaling mechanism: G protein-mediated signal transduction. Using time-resolved cryo-EM, the authors pieced… read more here.
Keywords: signal transduction; molecular choreography; protein mediated; protein ... See more keywords