Validating a molecular clock for nudibranchs—No fossils to the rescue
Sign Up to like & getrecommendations! Published in 2024 at "Ecology and Evolution"
DOI: 10.1002/ece3.11014
Abstract: Abstract Time calibrated phylogenies are typically reconstructed with fossil information but for soft‐bodied marine invertebrates that lack hard parts, a fossil record is lacking. In these cases, biogeographic calibrations or the rates of divergence for… read more here.
Keywords: validating molecular; divergence; fossils rescue; nudibranchs fossils ... See more keywords
The molecular clock in the skin, its functionality, and how it is disrupted in cutaneous melanoma: a new pharmacological target?
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03183-5
Abstract: The skin is the interface between the organism and the external environment, acting as its first barrier. Thus, this organ is constantly challenged by physical stimuli such as UV and infrared radiation, visible light, and… read more here.
Keywords: skin functionality; skin; molecular clock; clock skin ... See more keywords
Transcription-based circadian mechanism controls the duration of molecular clock states in response to signaling inputs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2019.110015
Abstract: The molecular oscillator of the mammalian circadian clock consists in a dynamical network of genes and proteins whose main regulatory mechanisms occur at the transcriptional level. From a dynamical point of view, the mechanisms leading… read more here.
Keywords: transcription based; mechanism; duration; molecular clock ... See more keywords
Restoration of the molecular clock is tumor suppressive in neuroblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24196-4
Abstract: MYCN activation is a hallmark of advanced neuroblastoma (NB) and a known master regulator of metabolic reprogramming, favoring NB adaptation to its microenvironment. We found that the expression of the main regulators of the molecular… read more here.
Keywords: clock tumor; restoration molecular; expression; molecular clock ... See more keywords
Regulation of molecular clock oscillations and phagocytic activity via muscarinic Ca2+ signaling in human retinal pigment epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep44175
Abstract: Vertebrate eyes are known to contain circadian clocks, however, the intracellular mechanisms regulating the retinal clockwork remain largely unknown. To address this, we generated a cell line (hRPE-YC) from human retinal pigmental epithelium, which stably… read more here.
Keywords: human retinal; clock oscillations; rhythms; molecular clock ... See more keywords
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1800431115
Abstract: Significance The molecular clock provides an anticipatory mechanism, allowing organisms to prepare and respond to daily changes in the external environment. The response of the innate immune system to pathogenic threats is dependent on time… read more here.
Keywords: bmal1; response; nrf2; molecular clock ... See more keywords
Myriapod divergence times differ between molecular clock and fossil evidence: U/Pb zircon ages of the earliest fossil millipede-bearing sediments and their significance
Sign Up to like & getrecommendations! Published in 2020 at "Historical Biology"
DOI: 10.1080/08912963.2020.1761351
Abstract: ABSTRACT Molecular clock calculations suggest a late Cambrian (~ 500 Ma) divergence of myriapod classes. Yet, the earliest myriapods only appear in the latest Silurian (~425 Ma). 75 million years later; though correlation with the… read more here.
Keywords: intermontane basin; myriapod; divergence; molecular clock ... See more keywords
Oscillation in expression of Adenylyl Cyclase isoforms: new insight to regulation of molecular clock
Sign Up to like & getrecommendations! Published in 2017 at "Biological Rhythm Research"
DOI: 10.1080/09291016.2016.1234756
Abstract: Abstract Background: Mammalian cells contain a cell-autonomous circadian clock that couples endogenous rhythms with changes of cellular environment. Some recent reports have been shown that circadian clock regulates glucose homeostasis; but, their molecular basis is… read more here.
Keywords: adenylyl cyclase; expression; molecular clock; clock ... See more keywords
Diversification dynamics of total-, stem-, and crown-groups are compatible with molecular clock estimates of divergence times
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abf2257
Abstract: A wide range of divergence times is supported by birth-death models under constant rates of speciation and extinction. Molecular evolutionary time scales are expected to predate the fossil evidence, but, particularly for major evolutionary radiations,… read more here.
Keywords: clock estimates; extinction; stem crown; molecular clock ... See more keywords
Recalibrating the molecular clock for Arctic marine invertebrates based on DNA barcodes 1.
Sign Up to like & getrecommendations! Published in 2019 at "Genome"
DOI: 10.1139/gen-2018-0107
Abstract: Divergence times for species assemblages of Arctic marine invertebrates have often been estimated using a standard rate (1.4%/MY) of molecular evolution calibrated using a single sister pair of tropical crustaceans. Because rates of molecular evolution… read more here.
Keywords: recalibrating molecular; marine; marine invertebrates; arctic marine ... See more keywords
Gut Microbial Metabolites Induce Changes in Circadian Oscillation of Clock Gene Expression in the Mouse Embryonic Fibroblasts
Sign Up to like & getrecommendations! Published in 2020 at "Molecules and Cells"
DOI: 10.14348/molcells.2020.2309
Abstract: Circadian rhythm is an endogenous oscillation of about 24-h period in many physiological processes and behaviors. This daily oscillation is maintained by the molecular clock machinery with transcriptional-translational feedback loops mediated by clock genes including… read more here.
Keywords: per2; ppa; oscillation; molecular clock ... See more keywords