Molecular Determinants of Carbocation Cyclisation in Bacterial Monoterpene Synthases
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202100688
Abstract: Monoterpene synthases are often promiscuous enzymes, yielding product mixtures rather than pure compounds due to the nature of the branched reaction mechanism involving reactive carbocations. Two previously identified bacterial monoterpene synthases, a linalool synthase (bLinS)… read more here.
Keywords: bacterial monoterpene; molecular determinants; monoterpene synthases; carbocation ... See more keywords
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03693-7
Abstract: Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an abnormal fibrotic response involving vast areas of the lungs. Given the poor… read more here.
Keywords: molecular determinants; idiopathic pulmonary; emerging cellular; pulmonary fibrosis ... See more keywords
Molecular determinants for the polarization of macrophage and osteoclast
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-019-00754-3
Abstract: Emerging evidence suggest that macrophage and osteoclast are two competing differentiation outcomes from myeloid progenitors. In this review, we summarize recent advances in the understanding of the molecular mechanisms controlling the polarization of macrophage and… read more here.
Keywords: molecular determinants; determinants polarization; macrophage; macrophage osteoclast ... See more keywords
Molecular determinants of protein-based coacervates
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Colloid and Interface Science"
DOI: 10.1016/j.cocis.2020.101407
Abstract: Abstract Protein-polyelectrolyte coacervates have gained interest for their potential to stabilize proteins or function as adhesives as well as their biological implications in the formation of membraneless organelles. To effectively design these materials or predict… read more here.
Keywords: phase separation; molecular determinants; protein polyelectrolyte; protein based ... See more keywords
Coding Molecular Determinants of Thyroid Cancer Development and Progression.
Sign Up to like & getrecommendations! Published in 2019 at "Endocrinology and metabolism clinics of North America"
DOI: 10.1016/j.ecl.2018.10.003
Abstract: Thyroid cancer is the most common endocrine malignancy. Its incidence and mortality rates have increased for patients with advanced-stage papillary thyroid cancer. The characterization of the molecular pathways essential in thyroid cancer initiation and progression… read more here.
Keywords: molecular determinants; determinants thyroid; coding molecular; progression ... See more keywords
Molecular determinants of obstructive sleep apnea.
Sign Up to like & getrecommendations! Published in 2021 at "Sleep medicine"
DOI: 10.1016/j.sleep.2021.01.032
Abstract: Obstructive sleep apnea (OSA) is characterized as recurrent episodes of obstruction in the upper airway during the period of sleep. The condition occurs in approximately 11% and 4% of middle-aged men and middle-aged women, respectively.… read more here.
Keywords: determinants obstructive; molecular determinants; biology; obstructive sleep ... See more keywords
Elucidation of the Molecular Determinants for Optimal Perfluorooctanesulfonate Adsorption Using a Combinatorial Nanoparticle Library Approach.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b01635
Abstract: Perfluorooctanesulfonate (PFOS) persistently accumulates in the environment and in humans, causing various toxicities. To determine the key molecular determinants for optimal PFOS specificity and efficiency, we designed and synthesized a combinatorial gold nanoparticle (GNP) library… read more here.
Keywords: molecular determinants; adsorption; nanoparticle; approach ... See more keywords
Probing the molecular determinants of fluorinase specificity.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc09213f
Abstract: Molecular determinants of FlA1 fluorinase specificity were probed using 5'-chloro-5'-deoxyadenosine (5'-ClDA) analogs as substrates and FlA1 active site mutants. Modifications at F213 or A279 residues are beneficial towards these modified substrates, including 5'-chloro-5'-deoxy-2-ethynyladenosine, ClDEA (>10-fold… read more here.
Keywords: determinants fluorinase; molecular determinants; probing molecular; fluorinase specificity ... See more keywords
Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1915562116
Abstract: Significance The human population contains thousands of MHC-I alleles, showing a range of dependencies on molecular chaperones for loading of their peptide cargo, which are then displayed on the cell surface for T cell surveillance.… read more here.
Keywords: molecular determinants; mhc molecules; determinants chaperone; mhc alleles ... See more keywords
Molecular determinants of pH sensing in the proton-activated chloride channel
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200727119
Abstract: Significance The acidic environment is critical for the proper function of many intracellular organelles. It is also associated with various diseases such as ischemia, cancer, and inflammation. In response to acidic pH, the proton-activated chloride… read more here.
Keywords: proton activated; molecular determinants; activated chloride; determinants sensing ... See more keywords
Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V
Sign Up to like & getrecommendations! Published in 2022 at "Channels"
DOI: 10.1080/19336950.2022.2053420
Abstract: ABSTRACT JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4.3 expressed in Xenopus… read more here.
Keywords: kv4 expressed; jztx; kv4; molecular determinants ... See more keywords