Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs.
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DOI: 10.1021/acs.jmedchem.8b01281
Abstract: Binding of drugs to ocular melanin is a prominent biological phenomenon that affects the local pharmacokinetics and pharmacodynamics in the eye. In this work, we report on the development of in vitro and in silico… read more here.
Keywords: binding support; melanin; molecular drivers; melanin binding ... See more keywords
Hypoxia-regulated microRNAs: the molecular drivers of tumor progression
Sign Up to like & getrecommendations! Published in 2022 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2022.2088684
Abstract: Abstract Hypoxia is a common feature of the tumor microenvironment (TME) of nearly all solid tumors, leading to therapeutic failure. The changes in stiffness of the extracellular matrix (ECM), pH gradients, and chemical balance that… read more here.
Keywords: hypoxia; mir; micrornas molecular; hypoxia regulated ... See more keywords
Proteomic profiling of tear fluid from offspring of Keratoconus patients: New insights into pathways and molecular drivers of disease development
Sign Up to like & getrecommendations! Published in 2024 at "Acta Ophthalmologica"
DOI: 10.1111/aos.15827
Abstract: Aims: To analyse the tear proteome of the offspring of Keratoconus (KC) patients in comparison with control subjects, trying to elucidate the molecular drivers underlying the risk of KC development in this population and providing… read more here.
Keywords: keratoconus patients; offspring keratoconus; fluid offspring; development ... See more keywords
Abstract IA01: Molecular drivers in hepatocellular carcinoma: The story of what we know and what are we missing
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.liverca22-ia01
Abstract: Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, both at the molecular and histological level. High-throughput sequencing and gene expression profiling have identified distinct transcriptomic subclasses and recurrently altered cancer driver genes. Several HCC subtypes… read more here.
Keywords: carcinoma story; hepatocellular carcinoma; drivers hepatocellular; story know ... See more keywords
The Genetic and Molecular Drivers of Multiple Myeloma: Current Insights, Clinical Implications, and the Path Forward
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DOI: 10.2147/pgpm.s350238
Abstract: Background Multiple myeloma (MM) is a hematological malignancy characterized by the clonal proliferation of malignant plasma cells within the bone marrow. The disease’s complexity is underpinned by a variety of genetic and molecular abnormalities that… read more here.
Keywords: myeloma current; multiple myeloma; drivers multiple; genetic molecular ... See more keywords
Developmental Cues and Molecular Drivers in Myelinogenesis: Revisiting Early Life to Re-Evaluate the Integrity of CNS Myelin
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44070222
Abstract: The mammalian central nervous system (CNS) coordinates its communication through saltatory conduction, facilitated by myelin-forming oligodendrocytes (OLs). Despite the fact that neurogenesis from stem cell niches has caught the majority of attention in recent years,… read more here.
Keywords: myelinogenesis revisiting; developmental cues; drivers myelinogenesis; cues molecular ... See more keywords