Nano-Mechanical Studies of Collagen: The Influence of Ionic Strength, pH and Collagen Sources on Molecular Flexibility
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2641
Abstract: Collagen, a key component of the extracellular matrix, is the most abundant protein in vertebrates, and is widely used in tissue engineering. Collagen is found in almost every connective tissue of the body, including skin,… read more here.
Keywords: collagen; molecular flexibility; flexibility; influence ... See more keywords
Molecular Flexibility of Antibodies Preserved Even in the Dense Phase after Macroscopic Phase Separation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00555
Abstract: Antibody therapies are typically based on high-concentration formulations that need to be administered subcutaneously. These conditions induce several challenges, inter alia a viscosity suitable for injection, sufficient solution stability, and preservation of molecular function. To… read more here.
Keywords: phase; antibodies preserved; flexibility antibodies; molecular flexibility ... See more keywords
Correlation between Self-Folding Behavior of Amphiphilic Polymers and Their Molecular Flexibility.
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DOI: 10.1021/acsmacrolett.3c00182
Abstract: Self-folding behavior of amphiphilic polymers in aqueous environments mimics the structures of biomacromolecules (e.g., proteins). Since both the three-dimensional structure (static) and the molecular flexibility (dynamic) of a protein are essential for its biological functions,… read more here.
Keywords: self folding; behavior amphiphilic; folding behavior; amphiphilic polymers ... See more keywords
Increased Molecular Flexibility Widens the Gap between K i and K d values in Screening for Retinoid X Receptor Modulators.
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DOI: 10.1021/acsmedchemlett.1c00575
Abstract: Screening for small-molecule modulators targeting a particular receptor is frequently based on measurement of K d, i.e., the binding constant between the receptor and the compound of interest. However, K d values also reflect binding… read more here.
Keywords: retinoid receptor; increased molecular; molecular flexibility; flexibility widens ... See more keywords
Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility
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DOI: 10.3390/biology10060454
Abstract: Simple Summary Nucleocapsid protein is one of the essential proteins for viral replication including the coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19) pneumonia leading to the ongoing pandemic. Whereas this protein has emerged as… read more here.
Keywords: molecular flexibility; flexibility; drug; sars cov ... See more keywords