Molecular Framework Analysis of the Generated Database GDB-13s
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01107
Abstract: The generated databases (GDBs) list billions of possible molecules from systematic enumeration following simple rules of chemical stability and synthetic feasibility. To assess the originality of GDB molecules, we compared their Bemis and Murcko molecular… read more here.
Keywords: database; gdb; molecular framework; framework analysis ... See more keywords
A molecular framework for grain number determination in barley
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add0324
Abstract: Flowering plants with indeterminate inflorescences often produce more floral structures than they require. We found that floral primordia initiations in barley (Hordeum vulgare L.) are molecularly decoupled from their maturation into grains. While initiation is… read more here.
Keywords: framework grain; number; molecular framework; grain number ... See more keywords
A molecular framework for autistic experiences: Mitochondrial allostatic load as a mediator between autism and psychopathology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.985713
Abstract: Molecular autism research is evolving toward a biopsychosocial framework that is more informed by autistic experiences. In this context, research aims are moving away from correcting external autistic behaviors and toward alleviating internal distress. Autism… read more here.
Keywords: autism; psychopathology; molecular framework; mitochondrial allostatic ... See more keywords
Molecular Framework of Mouse Endothelial Cell Dysfunction during Inflammation: A Proteomics Approach
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158399
Abstract: A key aspect of cytokine-induced changes as observed in sepsis is the dysregulated activation of endothelial cells (ECs), initiating a cascade of inflammatory signaling leading to leukocyte adhesion/migration and organ damage. The therapeutic targeting of… read more here.
Keywords: inflammation; ecs; organ specific; molecular framework ... See more keywords