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   Articles with "molecular functional" as a keyword



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Molecular and functional profiling of human islets: from heterogeneity to human phenotypes

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recommendations! Published in 2020 at "Diabetologia"

DOI: 10.1007/s00125-020-05159-8

Abstract: Efforts to phenotype pancreatic islets have contributed tremendously to our present understanding of endocrine function and diabetes. A continued evolution in approaches to study islet physiology is important given the need to establish reference points… read more here.

Keywords: human phenotypes; functional profiling; physiology; molecular functional ... See more keywords

Molecular and functional analysis of monoclonal antibodies in support of biologics development

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recommendations! Published in 2017 at "Protein & Cell"

DOI: 10.1007/s13238-017-0447-x

Abstract: Monoclonal antibody (mAb)-based therapeutics are playing an increasingly important role in the treatment or prevention of many important diseases such as cancers, autoimmune disorders, and infectious diseases. Multi-domain mAbs are far more complex than small… read more here.

Keywords: monoclonal antibodies; analysis; analysis monoclonal; molecular functional ... See more keywords

Molnupiravir; molecular and functional descriptors of mitochondrial safety

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recommendations! Published in 2022 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2022.116003

Abstract: Molnupiravir is an orally active nucleoside analog antiviral drug that recently was approved by the U.S. FDA for emergency treatment of adult patients infected with the SARS-CoV-2 (COVID-19) virus and at risk for severe progression.… read more here.

Keywords: molnupiravir molecular; molnupiravir; descriptors mitochondrial; functional descriptors ... See more keywords

Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-54138-9

Abstract: Genomic profiling often fails to predict therapeutic outcomes in cancer. This failure is, in part, due to a myriad of genetic alterations and the plasticity of cancer signaling networks. Functional profiling, which ascertains signaling dynamics,… read more here.

Keywords: molecular functional; intrinsic apoptotic; apoptotic machinery; functional characterization ... See more keywords

Molecular and functional analysis of chitin synthase genes in Chilo suppressalis (Lepidoptera: Crambidae).

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recommendations! Published in 2022 at "Insect science"

DOI: 10.1111/1744-7917.13134

Abstract: The rice stem borer, Chilo suppressalis, has developed a high level of resistance to many of the compounds used for control at present. There is thus an urgent need to develop novel control methods for… read more here.

Keywords: chitin; chitin synthase; synthase genes; chilo suppressalis ... See more keywords

Changes in the Molecular and Functional Phenotype of Bovine Monocytes during Theileria parva Infection

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recommendations! Published in 2019 at "Infection and Immunity"

DOI: 10.1128/iai.00703-19

Abstract: Theileria parva is the causative agent of East Coast fever (ECF), a tick-borne disease that kills over a million cattle each year in sub-Saharan Africa. Immune protection against T. parva involves a CD8+ cytotoxic T… read more here.

Keywords: theileria parva; infected cells; infection; parva infection ... See more keywords

Molecular and functional characterization of the Gulf toadfish serotonin transporter SLC6A4

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recommendations! Published in 2018 at "Journal of Experimental Biology"

DOI: 10.1242/jeb.170928

Abstract: ABSTRACT The serotonin transporter (SERT) functions in the uptake of the neurotransmitter serotonin (5-HT) from the extracellular milieu and is the molecular target of the selective serotonin re-uptake inhibitors (SSRIs), a common group of anti-depressants.… read more here.

Keywords: serotonin transporter; sert; serotonin; transporter ... See more keywords

Molecular and functional characterization of protease from psychrotrophic Bacillus sp. HM49 in North-western Himalaya

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recommendations! Published in 2023 at "PLOS ONE"

DOI: 10.1371/journal.pone.0283677

Abstract: In this work, a psychrotrophic bacteria producing cold-active protease, was obtained from Dachigam National Park, an ecologically significant habitat in Western Himalayas owing to its varied endemic and endangered flora and fauna. This isolate was… read more here.

Keywords: functional characterization; protease; bacillus hm49; characterization protease ... See more keywords
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Molecular and Functional Characterization of Circulating Tumor Cells: From Discovery to Clinical Application.

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recommendations! Published in 2019 at "Clinical chemistry"

DOI: 10.1373/clinchem.2019.303586

Abstract: BACKGROUND One of the objectives for the liquid biopsy is to become a surrogate to tissue biopsies in diagnosis of cancer as a minimally invasive method, with clinical utility in real-time follow-ups of patients. To… read more here.

Keywords: tumor cells; circulating tumor; biology; molecular functional ... See more keywords

Molecular and Functional Characterization of a Novel Plasmid-Borne blaNDM-Like Gene, blaAFM-1, in a Clinical Strain of Aeromonas hydrophila

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recommendations! Published in 2021 at "Infection and Drug Resistance"

DOI: 10.2147/idr.s297419

Abstract: Purpose An increasing frequency of antibiotic resistance has been observed in both clinical and environmental Aeromonas hydrophila isolates in recent years. However, there are still very few in-depth studies regarding the role of plasmids in… read more here.

Keywords: aeromonas hydrophila; plasmid borne; resistance; gene ... See more keywords

Molecular functional mechanisms of two alcohol acetyltransferases in Lavandula x intermedia (lavandin)

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recommendations! Published in 2025 at "Frontiers in Chemistry"

DOI: 10.3389/fchem.2025.1627286

Abstract: Volatile esters are key flavor components in most plants, including Lavandula x intermedia (lavandin). The final step in ester biosynthesis is catalyzed by Lavandula x intermedia alcohol acyltransferases (LiAATases), which attach alcohols to acyl groups.… read more here.

Keywords: molecular functional; intermedia lavandin; mechanisms two; functional mechanisms ... See more keywords