Molecular and functional profiling of human islets: from heterogeneity to human phenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Diabetologia"
DOI: 10.1007/s00125-020-05159-8
Abstract: Efforts to phenotype pancreatic islets have contributed tremendously to our present understanding of endocrine function and diabetes. A continued evolution in approaches to study islet physiology is important given the need to establish reference points… read more here.
Keywords: human phenotypes; functional profiling; physiology; molecular functional ... See more keywords
Molecular and functional analysis of monoclonal antibodies in support of biologics development
Sign Up to like & getrecommendations! Published in 2017 at "Protein & Cell"
DOI: 10.1007/s13238-017-0447-x
Abstract: Monoclonal antibody (mAb)-based therapeutics are playing an increasingly important role in the treatment or prevention of many important diseases such as cancers, autoimmune disorders, and infectious diseases. Multi-domain mAbs are far more complex than small… read more here.
Keywords: monoclonal antibodies; analysis; analysis monoclonal; molecular functional ... See more keywords
Molnupiravir; molecular and functional descriptors of mitochondrial safety
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2022.116003
Abstract: Molnupiravir is an orally active nucleoside analog antiviral drug that recently was approved by the U.S. FDA for emergency treatment of adult patients infected with the SARS-CoV-2 (COVID-19) virus and at risk for severe progression.… read more here.
Keywords: molnupiravir molecular; molnupiravir; descriptors mitochondrial; functional descriptors ... See more keywords
Molecular and functional analysis of chitin synthase genes in Chilo suppressalis (Lepidoptera: Crambidae).
Sign Up to like & getrecommendations! Published in 2022 at "Insect science"
DOI: 10.1111/1744-7917.13134
Abstract: The rice stem borer, Chilo suppressalis, has developed a high level of resistance to many of the compounds used for control at present. There is thus an urgent need to develop novel control methods for… read more here.
Keywords: chitin; chitin synthase; synthase genes; chilo suppressalis ... See more keywords
Changes in the Molecular and Functional Phenotype of Bovine Monocytes during Theileria parva Infection
Sign Up to like & getrecommendations! Published in 2019 at "Infection and Immunity"
DOI: 10.1128/iai.00703-19
Abstract: Theileria parva is the causative agent of East Coast fever (ECF), a tick-borne disease that kills over a million cattle each year in sub-Saharan Africa. Immune protection against T. parva involves a CD8+ cytotoxic T… read more here.
Keywords: theileria parva; infected cells; infection; parva infection ... See more keywords
Molecular and functional characterization of the Gulf toadfish serotonin transporter SLC6A4
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.170928
Abstract: ABSTRACT The serotonin transporter (SERT) functions in the uptake of the neurotransmitter serotonin (5-HT) from the extracellular milieu and is the molecular target of the selective serotonin re-uptake inhibitors (SSRIs), a common group of anti-depressants.… read more here.
Keywords: serotonin transporter; sert; serotonin; transporter ... See more keywords
Molecular and functional characterization of protease from psychrotrophic Bacillus sp. HM49 in North-western Himalaya
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0283677
Abstract: In this work, a psychrotrophic bacteria producing cold-active protease, was obtained from Dachigam National Park, an ecologically significant habitat in Western Himalayas owing to its varied endemic and endangered flora and fauna. This isolate was… read more here.
Keywords: functional characterization; protease; bacillus hm49; characterization protease ... See more keywords
Molecular and Functional Characterization of Circulating Tumor Cells: From Discovery to Clinical Application.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical chemistry"
DOI: 10.1373/clinchem.2019.303586
Abstract: BACKGROUND One of the objectives for the liquid biopsy is to become a surrogate to tissue biopsies in diagnosis of cancer as a minimally invasive method, with clinical utility in real-time follow-ups of patients. To… read more here.
Keywords: tumor cells; circulating tumor; biology; molecular functional ... See more keywords
Molecular and Functional Characterization of a Novel Plasmid-Borne blaNDM-Like Gene, blaAFM-1, in a Clinical Strain of Aeromonas hydrophila
Sign Up to like & getrecommendations! Published in 2021 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s297419
Abstract: Purpose An increasing frequency of antibiotic resistance has been observed in both clinical and environmental Aeromonas hydrophila isolates in recent years. However, there are still very few in-depth studies regarding the role of plasmids in… read more here.
Keywords: aeromonas hydrophila; plasmid borne; resistance; gene ... See more keywords
Cross-Species Genome-Wide Analysis Reveals Molecular and Functional Diversity of the Unconventional Interferon-ω Subtype
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01431
Abstract: Innate immune interferons (IFNs), particularly type I IFNs, are primary mediators regulating animal antiviral, antitumor, and cell-proliferative activity. These antiviral cytokines have evolved remarkable molecular and functional diversity to confront ever-evolving viral threats and physiological… read more here.
Keywords: diversity unconventional; molecular functional; cross species; functional diversity ... See more keywords
Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.600895
Abstract: Sensory perception is fundamental to everyday life, yet understanding of human sensory physiology at the molecular level is hindered due to constraints on tissue availability. Emerging strategies to study and characterize peripheral neuropathies in vitro… read more here.
Keywords: neurogenin; human sensory; physiology; molecular functional ... See more keywords