Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00245
Abstract: Targeted protein degradation is a rapidly exploding drug discovery strategy that uses small molecules to recruit disease-causing proteins for rapid destruction mainly via the ubiquitin–proteasome pathway. It shows great potential for treating diseases such as… read more here.
Keywords: drug discovery; targeted protein; protein degradation; molecular glues ... See more keywords
Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein–Protein Interaction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01635
Abstract: The ubiquitously expressed glucocorticoid receptor (GR) is a nuclear receptor that controls a broad range of biological processes and is activated by steroidal glucocorticoids such as hydrocortisone or dexamethasone. Glucocorticoids are used to treat a… read more here.
Keywords: protein protein; glucocorticoid receptor; designing selective; receptor ... See more keywords
A theranostic abscisic acid-based molecular glue
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc06995d
Abstract: Molecular glues, capable of selectively controlling the interactions between specific pairs or groups of proteins and the associated downstream effects, have become a promising strategy for manipulating cellular functions and developing novel therapies for human… read more here.
Keywords: glue; theranostic molecular; abscisic acid; molecular glue ... See more keywords
Targeted protein degradation and regulation with molecular glue: past and recent discoveries.
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867328666210806113949
Abstract: The evolution in research and clinical settings of targeted therapies has been inspired by the progress of cancer chemotherapy to use small molecules and monoclonal antibodies for targeting specific disease-associated genes and proteins for noninfectious… read more here.
Keywords: molecular glue; degradation regulation; protein degradation; targeted protein ... See more keywords
Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13215506
Abstract: Simple Summary Cyclin-dependent kinases (CDKs) are rich and viable therapeutic targets for various cancers. The emergence of event-driven pharmacology as an alternative to occupancy-driven pharmacology has begun to address the challenges associated with selectively targeting… read more here.
Keywords: protein; protacs molecular; cyclin dependent; therapeutic modalities ... See more keywords