Integrated analysis of tumor-associated macrophages and M2 macrophages in CRC: unraveling molecular heterogeneity and developing a novel risk signature
Sign Up to like & getrecommendations! Published in 2024 at "BMC Medical Genomics"
DOI: 10.1186/s12920-024-01881-z
Abstract: Background Emerging investigations have increasingly highlighted the critical role of tumor-associated macrophages (TAMs) and M2 macrophages in cancer development, progression, and metastasis, marking them as potential targets in various cancer types. The main objective of… read more here.
Keywords: analysis; tumor associated; molecular heterogeneity; seq ... See more keywords
Impact of cholangiocarcinoma (CC) molecular heterogeneity on outcome during first-line chemotherapy and access to targeted therapies in early clinical trials (CT).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.4091
Abstract: 4091Background: CC has poor prognosis and limited therapeutic options beyond first-line therapy. It is molecularly heterogeneous with several gene alterations (alt) that can be matched to targeted ... read more here.
Keywords: heterogeneity outcome; line; first line; molecular heterogeneity ... See more keywords
The molecular heterogeneity of sporadic colorectal cancer with different tumor sites in Chinese patients
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16176
Abstract: Purpose To assess the biological variability of clinical meaningful molecular markers and their clinical correlations in Chinese patients with colorectal cancer (CRC). Materials and methods In this prospective observational study, frequencies and clinico-pathological features of… read more here.
Keywords: right sided; colorectal cancer; molecular heterogeneity; chinese patients ... See more keywords
Deciphering the molecular heterogeneity of intermediate- and (very-)high-risk non–muscle-invasive bladder cancer using multi-layered –omics studies
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1424293
Abstract: Bladder cancer (BC) is the most common malignancy of the urinary tract. About 75% of all BC patients present with non-muscle-invasive BC (NMIBC), of which up to 70% will recur, and 15% will progress in… read more here.
Keywords: heterogeneity intermediate; intermediate high; risk; high risk ... See more keywords
Molecular Heterogeneity of Pediatric AML with Atypical Promyelocytes Accumulation in Children—A Single Center Experience
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14030675
Abstract: Acute promyelocytic leukemia (APL) pathogenesis is based on RARA gene translocations, which are of high importance in the diagnosis of and proper therapy selection for APL. However, in some cases acute myeloid leukemia (AML) demonstrates… read more here.
Keywords: atypical promyelocytes; molecular heterogeneity; promyelocytes accumulation; aml atypical ... See more keywords