Molecular Hybridization-Guided Construction of Convolutamydine A-fused β-Ionone Scaffolds and their Biological Evaluation for Anticancer Activities
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.3027
Abstract: Described herein is a facile and efficient methodology toward the synthesis of novel convolutamydine A-incorporated β-ionone scaffold 3 from an Aldol addition event of β-ionone to isatins via enamine Et2NH catalysis. Products featuring a quaternary… read more here.
Keywords: convolutamydine; molecular hybridization; ionone; guided construction ... See more keywords
Efficient click reaction towards novel sulfonamide hybrids by molecular hybridization strategy as antiproliferative agents
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-017-1415-y
Abstract: Abstract Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. The target sulfonamide hybrids were obtained in the click reaction of azide derivatives and commerciallly available alkynes. All sulfonamide hybrids were evaluated for their antiproliferative… read more here.
Keywords: click reaction; sulfonamide hybrids; molecular hybridization; novel sulfonamide ... See more keywords
Molecular hybridization combining tumor homing and penetrating peptide domains for cellular targeting.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery and translational research"
DOI: 10.1007/s13346-021-01035-z
Abstract: A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in vitro for cellular uptake and… read more here.
Keywords: peptide; tumor homing; combining tumor; molecular hybridization ... See more keywords
Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.02.047
Abstract: A novel series of uracil-bearing DAPYs derivatives were designed and synthesized via structure-based molecular hybridization to discover compounds with improved anti-resistance profiles. Anti-HIV activity of the designed compounds was tested in MT-4 cell cultures. The most… read more here.
Keywords: uracil bearing; based molecular; molecular hybridization; dapys derivatives ... See more keywords
MolHyb: A Web Server for Structure-Based Drug Design by Molecular Hybridization
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00443
Abstract: Molecular hybridization is a widely used ligand design method in drug discovery. In this study, we present MolHyb, a web server for structure-based ligand design by molecular hybridization. The input of MolHyb is a protein… read more here.
Keywords: structure; hybridization; design; molhyb ... See more keywords
Polyvalent Detection of Members of the Genus Potyvirus by Molecular Hybridization Using a Genus-Probe.
Sign Up to like & getrecommendations! Published in 2018 at "Phytopathology"
DOI: 10.1094/phyto-04-18-0146-r
Abstract: The use of a unique riboprobe named polyprobe, carrying partial sequences of different plant viruses or viroids fused in tandem, has permitted the polyvalent detection of up to 10 different pathogens by using a nonradioactive… read more here.
Keywords: genus probe; polyvalent detection; molecular hybridization; hybridization ... See more keywords
Identification of N-Benzylated Indole Mannich Bases as Potential Anti TB Agents by Using Computational Studies and Molecular Hybridization Technique.
Sign Up to like & getrecommendations! Published in 2018 at "Current computer-aided drug design"
DOI: 10.2174/1573409914666180423093049
Abstract: INTRODUCTION Morbidity and mortality due to tuberculosis are rising steadily. Despite having efficient drugs and treatment protocols, microbial drug resistance often leads to treatment failure. Efforts to bring novel drugs to combat this menace are… read more here.
Keywords: indole mannich; anti; mannich bases; molecular hybridization ... See more keywords
Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27185923
Abstract: We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among… read more here.
Keywords: using molecular; molecular hybridization; hybridization approach; sars cov ... See more keywords