Synthesis, antimicrobial evaluation, and in silico studies of quinoline—1H-1,2,3-triazole molecular hybrids
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10112-3
Abstract: Antimicrobial resistance has become a significant threat to global public health, thus precipitating an exigent need for new drugs with improved therapeutic efficacy. In this regard, molecular hybridization is deemed as a viable strategy to… read more here.
Keywords: triazole molecular; antimicrobial evaluation; silico studies; quinoline triazole ... See more keywords
Synthesis, spectroscopic investigations, DFT studies, molecular docking and antimicrobial potential of certain new indole-isatin molecular hybrids: Experimental and theoretical approaches
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DOI: 10.1016/j.molstruc.2017.10.025
Abstract: Abstract Indole-isatin molecular hybrids 5a-i have been synthesized and characterized by different spectroscopic methods to be evaluated as new antimicrobial agents against a panel of Gram positive bacteria, Gram negative bacteria, and moulds. Compound 5h… read more here.
Keywords: molecular hybrids; spectroscopic; isatin molecular; indole isatin ... See more keywords
Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents
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DOI: 10.1186/s13065-017-0344-7
Abstract: BackgroundAcyl hydrazones are an important class of heterocyclic compounds promising pharmacological characteristics. Malaria is a life-threatening mosquito-borne blood disease caused by a plasmodium parasite. In some places, malaria can be treated and controlled with early… read more here.
Keywords: novel acyl; design synthesis; hydrazone based; acyl hydrazone ... See more keywords
Synthesis, Molecular Modelling and Anticancer Activities of New Molecular Hybrids Containing 1,4-Naphthoquinone, 7-Chloroquinoline, 1,3,5-Triazine and Morpholine Cores as PI3K and AMPK Inhibitors in the Metastatic Melanoma Cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20190096
Abstract: Three molecular hybrids containing 1,4-naphthoquinones, 1,3,5-triazines, morpholine and 7-chloroquinoline, which have recognized contributions to the biological activity of many drugs, were synthesized in yields ranging from 43-84%. All hybrids were obtained in three steps starting… read more here.
Keywords: melanoma cells; molecular hybrids; pi3k ampk; metastatic melanoma ... See more keywords
A Review of Recent Advancements in Anti-tubercular Molecular Hybrids.
Sign Up to like & getrecommendations! Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170712164400
Abstract: Tuberculosis (TB) accounts for millions of deaths worldwide every year. Diverse survival strategies adopted by Mycobacterium tuberculosis (Mtb) have substantially hindered the existing anti-TB regimen thereby leading to multidrug-resistant (MDR) and extremely drug-resistant (XDR) strains… read more here.
Keywords: tubercular molecular; molecular hybrids; review recent; anti tubercular ... See more keywords
A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization
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DOI: 10.3390/ijms23074001
Abstract: Microtubules are cylindrical protein polymers formed from αβ-tubulin heterodimers in the cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the G2/M phase, and anomalous mitotic spindles will form. Microtubules are an… read more here.
Keywords: molecular hybrids; targeting tubulin; review recent; tubulin polymerization ... See more keywords
Design, Synthesis and Evaluation of Novel Molecular Hybrids between Antiglaucoma Drugs and H2S Donors
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DOI: 10.3390/ijms232213804
Abstract: Glaucoma is a group of eye diseases consisting of optic nerve damage with corresponding loss of field vision and blindness. Hydrogen sulfide (H2S) is a gaseous neurotransmitter implicated in various pathophysiological processes. It is involved… read more here.
Keywords: molecular hybrids; design synthesis; hybrids antiglaucoma; drugs h2s ... See more keywords