Small Molecular Inhibitors Reverse Cancer Metastasis by Blockading Oncogenic PITPNM3
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204649
Abstract: Most cancer‐related deaths are a result of metastasis. The development of small molecular inhibitors reversing cancer metastasis represents a promising therapeutic opportunity for cancer patients. This pan‐cancer analysis identifies oncogenic roles of membrane‐associated phosphatidylinositol transfer… read more here.
Keywords: metastasis; cancer metastasis; pitpnm3; small molecular ... See more keywords
Supramolecular Engineering of Molecular Inhibitors in an Adaptive Cytotoxic Nanoparticle for Synergistic Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b20178
Abstract: Combinatorial regimens that rationally pair molecular inhibitors with standard cytotoxic chemotherapeutics are used to improve therapeutic outcomes. Simultaneously engineering these therapies within a single nanocarrier that spans cytotoxic, antiangiogenic and anti-invasive mechanisms and that enables… read more here.
Keywords: engineering; nanoparticle; drug; molecular inhibitors ... See more keywords
Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment?
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00474-4
Abstract: To sustain their malignancy, tumour cells acquire several metabolic adaptations such as increased oxygen, glucose, glutamine, and lipids uptake. Other metabolic processes are also enhanced as part of tumour metabolic reprogramming, for example, increased serine… read more here.
Keywords: serine synthesis; small molecular; novo serine; cancer ... See more keywords
Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System
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DOI: 10.3390/molecules27238348
Abstract: The overuse of antibiotics has led to severe bacterial drug resistance. Blocking pathogen virulence devices is a highly effective approach to combating bacterial resistance worldwide. Type three secretion systems (T3SSs) are significant virulence factors in… read more here.
Keywords: small molecular; secretion; progress small; research progress ... See more keywords