Molecular insights into the mechanism of nonrecurrent F8 structural variants: Full breakpoint characterization and bioinformatics of DNA elements implicated in the upmost severe phenotype in hemophilia A
Sign Up to like & getrecommendations! Published in 2020 at "Human Mutation"
DOI: 10.1002/humu.23977
Abstract: Hemophilia A (HA) provides excellent models to analyze genotype–phenotype relationships and mutational mechanisms. NhF8ld's breakpoints were characterized using case‐specific DNA‐tags, direct‐ or inverse‐polymerase chain reaction amplification, and Sanger sequencing. DNA‐break's stimulators (n = 46), interspersed repeats, non‐B‐DNA,… read more here.
Keywords: phenotype; breakpoint; severe phenotype; molecular insights ... See more keywords
Molecular insights into sensing, regulation and improving of heat tolerance in plants.
Sign Up to like & getrecommendations! Published in 2021 at "Plant cell reports"
DOI: 10.1007/s00299-021-02793-3
Abstract: Climate-change-mediated increase in temperature extremes has become a threat to plant productivity. Heat stress-induced changes in growth pattern, sensitivity to pests, plant phonologies, flowering, shrinkage of maturity period, grain filling, and increased senescence result in… read more here.
Keywords: heat; heat stress; molecular insights; heat tolerance ... See more keywords
Molecular Insights into Therapeutic Potentials of Hybrid Compounds Targeting Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02779-6
Abstract: Alzheimer's disease (AD) is one of the most complex progressive neurological disorders involving degeneration of neuronal connections in brain cells leading to cell death. AD is predominantly detected among elder people (> 65 years), mostly diagnosed with… read more here.
Keywords: therapeutic compounds; hybrid compounds; hybrid molecules; molecular insights ... See more keywords
Comprehensive molecular insights into the stress response dynamics of rice (Oryza sativa L.) during rice tungro disease by RNA-seq-based comparative whole transcriptome analysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biosciences"
DOI: 10.1007/s12038-020-9996-x
Abstract: Rice tungro is a serious viral disease of rice resulting from infection by two viruses, Rice tungro bacilliform virus and Rice tungro spherical virus. To gain molecular insights into the global gene expression changes in… read more here.
Keywords: rice; comparative whole; molecular insights; stress response ... See more keywords
Molecular Insights into Compound-Transporter Interactions: The Case of Inhibitors of Gram-Negative Bacteria Efflux Pumps
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1483
Abstract: The Escherichia coli AcrAB-TolC efflux pump is the archetype of the Resistance-Nodulation-cell Division (RND) exporters from Gram-negative bacteria. Overexpression of RND-type efflux pumps is a major factor in multidrug resistance (MDR), which makes these polyspecific… read more here.
Keywords: gram negative; compound transporter; negative bacteria; molecular insights ... See more keywords
Molecular Insights into Variable Electron Transfer in Amphibian Cryptochrome.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.04.014
Abstract: Cryptochrome proteins are activated by the absorption of blue light, leading to the formation of radical pairs through electron transfer in the active site. Recent experimental studies have shown that once some of the amino… read more here.
Keywords: transfer pathways; electron transfer; molecular insights; electron ... See more keywords
Molecular Insights on the Release of Avibactam from the Acyl-Enzyme Complex.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.03.027
Abstract: Avibactam is a non-β-lactam β-lactamase inhibitor for treating complicated urinary tract and respiratory infections caused by multidrug-resistant bacterial pathogens, a serious public health threat. Despite its importance, the release mechanism of avibactam from the enzyme-inhibitor… read more here.
Keywords: avibactam acyl; molecular insights; insights release; release avibactam ... See more keywords
Molecular insights into ether-based electrolytes for Li-FeS2 batteries
Sign Up to like & getrecommendations! Published in 2018 at "Energy Storage Materials"
DOI: 10.1016/j.ensm.2017.12.003
Abstract: Abstract Lithium-FeS2 is an attractive chemistry for rechargeable lithium batteries because of its high theoretical energy density ~1313 Wh kg−1. However, fast capacity fade is generally observed in this system due to the irreversible dissolution of active… read more here.
Keywords: ether based; fes2; based electrolytes; insights ether ... See more keywords
Molecular insights of newly identified potential peptide inhibitors of hypoxia inducible factor 1α causing breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.09.072
Abstract: Abstract Breast cancer is one of the leading cancer types in women across the world. Computer aided drug designing have been widely applied for drug development and discovery of potential drug molecule of many over… read more here.
Keywords: hif; insights newly; cancer; breast cancer ... See more keywords
Molecular Insights into Extracellular Polymeric Substances in Activated Sludge.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental science & technology"
DOI: 10.1021/acs.est.0c00850
Abstract: Extracellular polymeric substances (EPS) are known to crucially affect the properties and performances of activated sludge, but the detailed influential mechanisms and the pertinence to specific compositional, structural properties of EPS are still elusive. Such… read more here.
Keywords: sludge eps; extracellular polymeric; molecular insights; activated sludge ... See more keywords
Molecular Insights into NO-Promoted Sulfate Formation on Model TiO2 Nanoparticles with Different Exposed Facets.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental science & technology"
DOI: 10.1021/acs.est.8b02688
Abstract: In this study, molecular insights into NO-promoted SO2 oxidation on model TiO2 with well-defined (001), (010), and (101) facets are investigated in the laboratory. The adsorbed SO2 is significantly promoted to transform into sulfate by… read more here.
Keywords: sulfate formation; promoted sulfate; insights promoted; molecular insights ... See more keywords