SA74 GENETIC UNDERPINNINGS OF SOCIAL WITHDRAWAL IN THE GENERAL POPULATION
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.146
Abstract: Background Social withdrawal is present as a trait in the general population and is a common early symptom of neuropsychiatric conditions such as Alzheimer's Disease (AD), Schizophrenia (SCZ) and Major Depressive Disorder (MDD). However, the… read more here.
Keywords: general population; withdrawal general; molecular landscape; withdrawal ... See more keywords
The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Sign Up to like & getrecommendations! Published in 2018 at "Nature Medicine"
DOI: 10.1038/nm.4439
Abstract: We present the molecular landscape of pediatric acute myeloid leukemia (AML) and characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The COG–National Cancer Institute (NCI) TARGET AML initiative assessed cases by whole-genome,… read more here.
Keywords: myeloid leukemia; molecular landscape; acute myeloid; pediatric acute ... See more keywords
Molecular landscape of long noncoding RNAs in brain disorders
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00947-5
Abstract: According to current paradigms, various risk factors, such as genetic mutations, oxidative stress, neural network dysfunction, and abnormal protein degradation, contribute to the progression of brain disorders. Through the cooperation of gene transcripts in biological… read more here.
Keywords: long noncoding; brain disorders; molecular landscape; noncoding rnas ... See more keywords
Molecular landscape of thymic epithelial tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in diagnostic pathology"
DOI: 10.1053/j.semdp.2021.06.011
Abstract: Thymic epithelial tumors (TETs) are extremely rare and represent the most frequent tumors of the anterior mediastinum originating from epithelial cells in the thymus. Thymic epithelial tumors include thymomas (TM), thymic carcinomas (TC) and thymic… read more here.
Keywords: pathology; landscape thymic; molecular landscape; thymic epithelial ... See more keywords
Elucidating the molecular landscape of the stratum corneum
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114380119
Abstract: Significance Skin is recognized as an intricate assembly of molecular components, which facilitate cell signaling, metabolism, and protein synthesis mechanisms in order to offer protection, regulation, and sensation to the body. Our study takes significant… read more here.
Keywords: stratum corneum; elucidating molecular; molecular landscape; landscape stratum ... See more keywords
How to treat histone 3 altered gliomas: molecular landscape and therapeutic developments
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2023.2163385
Abstract: ABSTRACT Introduction Diffuse midline gliomas (DMG) and diffuse hemispheric glioma (DHG) are both rare tumors characterized and recognized for specific alterations of histone 3 including H3K27 (DMG) and H3G34 (DHG). Despite these tumors arising from… read more here.
Keywords: treat histone; histone altered; molecular landscape; altered gliomas ... See more keywords
Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac186
Abstract: BACKGROUND Improved treatment of glioblastoma (GBM) needs to address tumor invasion, a hallmark of the disease that remains poorly understood. In this study, we profiled GBM invasion through integrative analysis of histological and single-cell RNA… read more here.
Keywords: molecular landscape; analysis; invasion; cellular molecular ... See more keywords
Molecular landscape of esophageal cancer: implications for early detection and personalized therapy
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.13876
Abstract: Esophageal cancer (EC) is one of the most lethal cancers and a public health concern worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are… read more here.
Keywords: esophageal cancer; esophageal; molecular landscape; therapy ... See more keywords
Molecular landscape of gastric cancer (GC) harboring mutations of histone methyltransferases.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.418
Abstract: 418Background: Alteration of histone modifications participating in transcription and genomic instability, has been recognized as an important role in tumorigenesis. Aberrant expression of histone-... read more here.
Keywords: gastric cancer; cancer harboring; landscape gastric; molecular landscape ... See more keywords
OR13-5 The Molecular Landscape of Osteogenesis Imperfecta in a Brazilian Tertiary Service Cohort
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-or13-5
Abstract: Abstract Osteogenesis imperfecta (OI) is clinically and genetically heterogeneous. Defects in collagen type 1 are reportedly the main cause of OI (85-90%), but most available data has arisen from developed countries. Massively parallel sequencing (MPS)… read more here.
Keywords: cohort; diagnosis; molecular landscape; osteogenesis imperfecta ... See more keywords
A Molecular Landscape of Mouse Hippocampal Neuromodulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2022.836930
Abstract: Adaptive neuronal circuit function requires a continual adjustment of synaptic network parameters known as “neuromodulation.” This process is now understood to be based primarily on the binding of myriad secreted “modulatory” ligands such as dopamine,… read more here.
Keywords: network; hippocampal neuromodulation; mouse hippocampal; molecular landscape ... See more keywords